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Effects of 2-Chloro-3- ( 4-cyanophenylamino ) -1 , 4-naphthoquinone ( NQ-Y15 ) on Normal and Ischemical / Reperfused Rat Hearts

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dc.contributor.author문, 창현-
dc.contributor.author김, 지영-
dc.contributor.author백, 은주-
dc.contributor.author이, 수환-
dc.contributor.author류, 충규-
dc.date.accessioned2012-03-22T02:20:11Z-
dc.date.available2012-03-22T02:20:11Z-
dc.date.issued1997-
dc.identifier.issn0377-9556-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6256-
dc.description.abstractStudies on the effect of quinones on cardiac function has been conducted with normal hearts. But not with injured hearts, I.e. ischemia/reperfusion-injured heart. Quinone compounds are known to produce oxygen free radicals during metabolism, and for this reason, quinones are implicated in the aggravation of ischemia/reperfusion injury or cardioprotection, as in the case of ischemic preconditioning depending on the experimental conditions. The present study was carried out to examine the effect of 2-chloro-3-(4-cyanophenylamino)-1.4-naphthoquinone (NQ-Y15) on cardiac function of ischemic/reperfused and normal rat hearts. In isolated perfused hearts, various functional parameters such as left ventricular developed pressure (LVDP), left ventricular end-diastolic pressure (EDP) and maximum positive and negative dP/dt (), time to contracture, heart rate (HR) and coronary flow rate (CFR) were measured before and 30 min after dosing and following 25 min ischemia/30min reperfusion. NQ-Y15 increased LVDP, +dP/and -dP/ by 18%. 30%, and 40%, respectively. There were no significant changes in other haemodynamic parameters. After ischemia/reperfusion injury, pretreatment with NQ-Y15 induced a significant decrease in LVDP and , but an increase in EDP. LDH-release was not significantly increased. These results suggested that NQ-Y15 may augment the ventricular contractility but it makes hearts more vulnerable to ischemia/reperfusion injury.-
dc.language.isoko-
dc.titleEffects of 2-Chloro-3- ( 4-cyanophenylamino ) -1 , 4-naphthoquinone ( NQ-Y15 ) on Normal and Ischemical / Reperfused Rat Hearts-
dc.title.alternative정상 및 허혈 / 재관류 흰쥐 심장에 대한 2-클로로-3- ( 4-시아노페닐아미노 ) -1 , 4-나프토퀴논 ( NQ-Y15 ) 의 작용-
dc.typeArticle-
dc.identifier.urlhttp://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0370219970410060829-
dc.subject.keywordHeart-
dc.subject.keywordReperfusion-
dc.subject.keywordIschemia-
dc.subject.keywordNQ-Y15-
dc.type.localJournal Papers-
dc.citation.titleYakhakhoe chi-
dc.citation.titleJournal of the Pharmaceutical Society of Korea-
dc.citation.title약학회지-
dc.citation.volume41-
dc.citation.number6-
dc.citation.date1997-
dc.citation.startPage829-
dc.citation.endPage836-
dc.identifier.bibliographicCitationYakhakhoe chi, 41(6):829-836, 1997-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
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