Determination of 3 , 4-Dimethylhippuric Acid and Creatinine from the Urine of Workers Exposed to 1 , 2 , 4-Trimethylbenzene
1 , 2 , 4-트리메틸벤젠에 피폭된 노동자의 뇨 중 3 , 4-디메틸히푸르 산과 크레아티닌의 정량
임, 정미; 장, 재연; 이, 용문; 강, 종성
Yakhakhoe chi, 41(6):692-697, 1997
Yakhakhoe chi; Journal of the Pharmaceutical Society of Korea; 약학회지
Creatine and 3,4-Dimethylhippuric acid (3,4-DMHA), a glycine conjugate of 1,2,4-trimethyl-benzene (1,2,4-TMB) were determined in the urine of workers exposed to 1,2,4-TMB vapor. The best condition for the simultaneous determination of 3,4-DMHA and creatine by high performance liquid chromatography was obtained by reverse phase column (4.6150mm, 5) as stationary phase and 20% acetonitrile in 20mM phosphate buffer (pH 3.0) containing 4mM sodium octylsulfate(SOS)as mobile phase. The recovery of 3,4-DMHA spiked to blank urine in the range of 1~5/ml was about 96%. The concentration of urinary 3,4-DMHA of workers had a positive correlation with the environmental level of 1,2,4-TMB (r=0.866). The data suggest that urinary 3,4-DMHA concentration is a useful biological index for 1,2,4-TMB exposure.
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