Comparison of Biochemical Bone Markers in Postmenopausal Women

Abstract

Biochemical bone markers, specifically intact bone gla protein(BGP:osteocalcin), N-Mid BGP, total alkaline phosphatase(ALP), bone ALP, procollagen type I C-terminal propeptide(PICP), type I collagen C-terminal telopeptide(ICTP), deoxypyridinoline(DPD), were measured in Korean post-menopausal women who came to Ajou University Hospital. Most of the biochemical bone markers significantly correlated with one another. Total ALP, N-Mid BGP, intact BGP had significant correlation with femoral neck BMD. Multiple regression analysis revealed that ICTP was significant biochemical bone marker which influenced spine BMD. It also revealed that N-Mid BGP was significant biochemical bone markers influencing femoral neck BMD. In conclusion, biochemical bone markers in Korean postmenopausal women had significant correlation with one another, and some of them were important factors influencing bone mineral densities.