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Correlation of serum Interleukin 8 with clinical disease activity in systemic lupus erythematosus (SLE)

Other Title
전신성 홍반성 루푸스 환자에서 임상적 질병 활성도와 혈청 인터루킨 8과의 연관성
Authors
이, 원기; 송, 창호; 박, 용범; 이, 충원; 서, 창희; 이, 찬희; 이, 지수; 김, 동수; 이, 수곤
Citation
The Korean journal of medicine, 54(6):770-777, 1998
Journal Title
The Korean journal of medicine; 대한내과학회지
ISSN
1738-93642289-0769
Abstract
Objectives : To evaluate seam Interleukin 8 (IL-8) as a predictor of disease activity in

SLE and to provide insight into the potential role of IL-8 in the pathogenesis of SLE.

Methods : Sixty-four paired sera from the 32 SLE patients and 10 healthy control

sera were obtained. Serum IL-8 levels were determined by ELISA technique. Tests for

other laboratory parameters, such as circulating immune complex (CIC), C3, C4, ANA, anti-dsDNA, Hb, Hct, leukocyte, lymphocyte, platelet and ESR were per(orbed for every sample coincidently with) assessment of clinical disease activity by the Lahita scales.

Results ; We found that serum IL-8 levels in SLE patients were significantly higher

than those of healthy controls. serum IL-8 levels significantly correlated with clinical disease activity. Serum IL-8 levels correlated with CIC, but it had no correlation with other laboratory parameters.

Conclusion : These findings suggest that serum IL-8 can be used as a marker of

disease activity in patients with SLE. These results may have implication in the

pathogenesis of SLE.
Keywords
systemic lupus erythematosusclinical disease activityinterleukin 8
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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