The Korean journal of medicine, 54(6):770-777, 1998
The Korean journal of medicine; 대한내과학회지
Objectives : To evaluate seam Interleukin 8 (IL-8) as a predictor of disease activity in
SLE and to provide insight into the potential role of IL-8 in the pathogenesis of SLE.
Methods : Sixty-four paired sera from the 32 SLE patients and 10 healthy control
sera were obtained. Serum IL-8 levels were determined by ELISA technique. Tests for
other laboratory parameters, such as circulating immune complex (CIC), C3, C4, ANA, anti-dsDNA, Hb, Hct, leukocyte, lymphocyte, platelet and ESR were per(orbed for every sample coincidently with) assessment of clinical disease activity by the Lahita scales.
Results ; We found that serum IL-8 levels in SLE patients were significantly higher
than those of healthy controls. serum IL-8 levels significantly correlated with clinical disease activity. Serum IL-8 levels correlated with CIC, but it had no correlation with other laboratory parameters.
Conclusion : These findings suggest that serum IL-8 can be used as a marker of
disease activity in patients with SLE. These results may have implication in the
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