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Effect of vitamin C on plasma total antioxidant status(TAS) in patients with paraquat intoxication

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dc.contributor.author홍, 세용-
dc.contributor.author은, 수훈-
dc.contributor.author한, 찬희-
dc.contributor.author윤, 영근-
dc.contributor.author양, 동호-
dc.contributor.author조, 성란-
dc.contributor.author김, 휘준-
dc.contributor.author한, 찬수-
dc.contributor.author박, 영현-
dc.description.abstractBackground : This study was undertaken to evaluate the effect of plasma concentration of vitamin C is on the plasma total antioxidant status(TAS) in patients with paraquat intoxication. Methods : As a preliminary research for this study, we

measured plasma vitamin C levels, uric acid, TAS, and bilirubin from 100 healthy Koreans aged between 25-55 years. Various concentrations of vitamin C were constructed in vitro with normal pooled plasma between 1mg/dl and 100 mg/dL and TAS was measured.

Both vitamin C concentrations and TAS were measured from the blood samples, taken at 0.5, 1, 2, 3, 5, 7, 9 hours after a bolus injection of vitamin C(50 mg/kg) from 7 volunteers who had been recruited from medical students at our hospital. Various

amounts of vitamin C were given to 10 patients with paraquat intoxication for 5 consecutive days in the morning : first day ; 100 mg single dose, second day; 500 mg single dose, third day ; 1,000 mg single dose, fourth day : 3,000 mg single dose, and fifth day ; 3,000 mg three times every 8 hours. Results : The mean value of TAS and vitamin C measured in 100 healthy Korean adults was 2.22 ±0.16 mmol/L and 0.48±0.10 mg/dL. Age and sex do not influence these levels(p>0.05, data are not presented). A

direct correlation was observed between TAS and vitamin C concentrations of 1 mg/dL and 100 mg/dL both in vivo and vitro. As the vitamin C concentration was increased gradually 5 consecutive days, the TAS values increased in the same way as follows :

first day(vitamin C 100 mg) 2.26±0.98 mmol/L, second day(vitamin C 500 mg) 2.76±0.78 mmol/L, third day(vitamin C 1.000 mg) 2.81±0.68 mmol/L, fourth day(vitamin C 3.000 mg) 3.18 mmol/L. On the fifth day when 3.000 mg of vitamin C was given by bolus

intravenous injection 3 times(every 8 hours for a day), the TAS values measured one hour after the injection was 3.58±0.37 mmol/L. Conclusion : When vitamin C is used as a free radical scavenger, the loading dose and maintenance dose should be around 2278 mg intravenous bolus and 146 mg/hour. High doses of vitamin C are effective and safe for patients with acute paraquat intoxication.
dc.titleEffect of vitamin C on plasma total antioxidant status(TAS) in patients with paraquat intoxication-
dc.title.alternative제초제 Paraquat 중독환자에서 vitamin C 투여가 plasma total antioxidant capacity에 미치는 영향-
dc.subject.keywordFree radical scavengers-
dc.subject.keywordAscorbic acid-
dc.subject.keywordPulmonary fibrosis-
dc.type.localJournal Papers-
dc.citation.titleThe Korean journal of medicine-
dc.identifier.bibliographicCitationThe Korean journal of medicine, 58(6):666-674, 2000-
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Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
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