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Antiplatelet effects of Cyperus rotundus and its component (+)-nootkatone

Authors
Seo, EJ; Lee, DU; Kwak, JH; Lee, SM; Kim, YS; Jung, YS
Citation
Journal of ethnopharmacology, 135(1):48-54, 2011
Journal Title
Journal of ethnopharmacology
ISSN
0378-87411872-7573
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus rotundus, a well-known oriental traditional medicine, has been reported to exhibit wide spectrum activity in biological systems including the circulatory system, however, little information is available on its antiplatelet activity. This study was undertaken to investigate the antiplatelet effects of Cyperus rotundus EtOH extract (CRE) and its constituent compounds.



MATERIALS AND METHODS: The antiplatelet activities of CRE and its eight constituent compounds were evaluated by examining their effects on rat platelet aggregations in vitro and ex vivo, and on mice tail bleeding times.



RESULTS: During the in vitro platelet aggregation study, CRE showed significant and concentration-dependent inhibitory effects on collagen-, thrombin-, and/or AA-induced platelet aggregation. Of its eight components, (+)-nootkatone was found to have the most potent inhibitory effect on collagen-, thrombin-, and AA-induced platelet aggregation. In addition, CRE- and (+)-nootkatone-treated mice exhibited significantly prolonged bleeding times. Furthermore, (+)-nootkatone had a significant inhibitory effect on rat platelet aggregation ex vivo.



CONCLUSIONS: This study demonstrates the antiplatelet effects of CRE and its active component (+)-nootkatone, and suggests that these agents might be of therapeutic benefit for the prevention of platelet-associated cardiovascular diseases.
MeSH terms
AnimalsArachidonic AcidBleeding TimeCollagenCyperus/*chemistryMiceMice, Inbred ICRPlant Extracts/*pharmacologyPlatelet Aggregation/*drug effectsPlatelet Aggregation Inhibitors/*pharmacologyRatsRats, Sprague-DawleySesquiterpenes/*pharmacologyThrombin
DOI
10.1016/j.jep.2011.02.025
PMID
21354294
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
정, 이숙
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