295 468

Cited 24 times in

Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice

DC Field Value Language
dc.contributor.authorSuh, YH-
dc.contributor.authorYoshimoto-Furusawa, A-
dc.contributor.authorWeih, KA-
dc.contributor.authorTessarollo, L-
dc.contributor.authorRoche, KW-
dc.contributor.authorMackem, S-
dc.contributor.authorRoche, PA-
dc.date.accessioned2012-03-29-
dc.date.available2012-03-29-
dc.date.issued2011-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6350-
dc.description.abstractSNARE-mediated membrane fusion is a pivotal event for a wide-variety of biological processes. SNAP-25, a neuron-specific SNARE protein, has been well-characterized and mouse embryos lacking Snap25 are viable. However, the phenotype of mice lacking SNAP-23, the ubiquitously expressed SNAP-25 homolog, remains unknown. To reveal the importance of SNAP-23 function in mouse development, we generated Snap23-null mice by homologous recombination. We were unable to obtain newborn SNAP-23-deficient mice, and analysis of pre-implantation embryos from Snap23(Δ/wt) matings revealed that Snap23-null blastocysts were dying prior to implantation at embryonic day E3.5. Thus these data reveal a critical role for SNAP-23 during embryogenesis.-
dc.language.isoen-
dc.subject.MESHAlleles-
dc.subject.MESHAnimals-
dc.subject.MESHBlastocyst/cytology/metabolism-
dc.subject.MESHBreeding-
dc.subject.MESHCell Death-
dc.subject.MESH*Embryo Implantation-
dc.subject.MESHEmbryo Loss/*metabolism/*pathology-
dc.subject.MESHFemale-
dc.subject.MESH*Gene Deletion-
dc.subject.MESHGene Targeting-
dc.subject.MESHHeterozygote-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHPregnancy-
dc.subject.MESHQb-SNARE Proteins/*deficiency/metabolism-
dc.subject.MESHQc-SNARE Proteins/*deficiency/metabolism-
dc.titleDeletion of SNAP-23 results in pre-implantation embryonic lethality in mice-
dc.typeArticle-
dc.identifier.pmid21479242-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066230/-
dc.contributor.affiliatedAuthor서, 영호-
dc.type.localJournal Papers-
dc.identifier.doi10.1371/journal.pone.0018444-
dc.citation.titlePloS one-
dc.citation.volume6-
dc.citation.number3-
dc.citation.date2011-
dc.citation.startPagee18444-
dc.citation.endPagee18444-
dc.identifier.bibliographicCitationPloS one, 6(3):e18444-e18444, 2011-
dc.identifier.eissn1932-6203-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
Files in This Item:
21479242.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse