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Effects of immunization with the rNfa1 protein on experimental Naegleria fowleri-PAM mice

DC Field Value Language
dc.contributor.authorLee, YJ-
dc.contributor.authorKim, JH-
dc.contributor.authorSohn, HJ-
dc.contributor.authorLee, J-
dc.contributor.authorJung, SY-
dc.contributor.authorChwae, YJ-
dc.contributor.authorKim, K-
dc.contributor.authorPark, S-
dc.contributor.authorShin, HJ-
dc.date.accessioned2012-03-29T01:39:49Z-
dc.date.available2012-03-29T01:39:49Z-
dc.date.issued2011-
dc.identifier.issn0141-9838-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6358-
dc.description.abstractFree-living Naegleria fowleri causes primary amoebic meningoencephalitis (PAM) in humans and animals. To examine the effect of immunization with Nfa1 protein on experimental murine PAM because of N. fowleri, BALB/c mice were intra-peritoneally or intra-nasally immunized with a recombinant Nfa1 protein. We analysed Nfa1-specific antibody and cytokine induction, and the mean survival time of infected mice. Mice immunized intra-peritoneally or intra-nasally with rNfa1 protein developed specific IgG, IgA and IgE antibodies; the IgG response was dominated by IgG1, followed by IgG2b, IgG2a and IgG3. High levels of the Th1 cytokine, IFN-γ, and the regulatory cytokine, IL-10, were also induced. The mean survival time of mice immunized intra-peritoneally with rNfa1 protein was prolonged compared with controls, (25.0 and 15.5 days, respectively). Similarly, the mean survival time of mice immunized intra-nasally with rNfa1 protein was 24.7 days, compared with 15.0 days for controls.-
dc.language.isoen-
dc.subject.MESHAdministration, Intranasal-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Protozoan/blood-
dc.subject.MESHAntigens, Protozoan/genetics/*immunology-
dc.subject.MESHCentral Nervous System Protozoal Infections/immunology/*prevention & control-
dc.subject.MESHCytokines/secretion-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHImmunoglobulin A/blood-
dc.subject.MESHImmunoglobulin E/blood-
dc.subject.MESHImmunoglobulin G/blood-
dc.subject.MESHInjections, Intraperitoneal-
dc.subject.MESHLeukocytes, Mononuclear/immunology-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHNaegleria fowleri/*immunology/pathogenicity-
dc.subject.MESHProtozoan Proteins/genetics/*immunology-
dc.subject.MESHProtozoan Vaccines/administration & dosage/genetics/*immunology-
dc.subject.MESHRodent Diseases/prevention & control-
dc.subject.MESHSpleen/immunology-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHVaccines, Synthetic/administration & dosage/genetics/immunology-
dc.titleEffects of immunization with the rNfa1 protein on experimental Naegleria fowleri-PAM mice-
dc.typeArticle-
dc.identifier.pmid21535019-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0141-9838&date=2011&volume=33&issue=7&spage=382-
dc.contributor.affiliatedAuthor김, 종현-
dc.contributor.affiliatedAuthor최, 용준-
dc.contributor.affiliatedAuthor김, 경민-
dc.contributor.affiliatedAuthor박, 선-
dc.contributor.affiliatedAuthor신, 호준-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1365-3024.2011.01296.x-
dc.citation.titleParasite immunology-
dc.citation.volume33-
dc.citation.number7-
dc.citation.date2011-
dc.citation.startPage382-
dc.citation.endPage389-
dc.identifier.bibliographicCitationParasite immunology, 33(7):382-389, 2011-
dc.identifier.eissn1365-3024-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Microbiology

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