36 321

Cited 151 times in

Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits

Authors
Kim, YJ; Go, MJ; Hu, C; Hong, CB; Kim, YK; Lee, JY; Hwang, JY; Oh, JH; Kim, DJ; Kim, NH; Kim, S; Hong, EJ; Kim, JH; Min, H; Kim, Y; Zhang, R; Jia, W; Okada, Y; Takahashi, A; Kubo, M; Tanaka, T; Kamatani, N; Matsuda, K; Park, T; Oh, B; Kimm, K; Kang, D; Shin, C; Cho, NH; Kim, HL; Han, BG; Cho, YS
Citation
Nature genetics, 43(10):990-995, 2011
Journal Title
Nature genetics
ISSN
1061-40361546-1718
Abstract
To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the BioBank Japan genome-wide association study and individuals comprising the Health2 and Shanghai Jiao Tong University Diabetes cohorts). We identified ten genome-wide significant signals newly associated with traits from an overall meta-analysis. The most compelling associations involved 12q24.11 (near MYL2) and 12q24.13 (in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11 (near MYL2), 12q24.13 (in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits. These findings highlight previously unknown biological pathways for metabolic traits investigated in this study.
MeSH terms
AdultAgedAsian Continental Ancestry Group/*geneticsBlood Glucose/analysis/geneticsCase-Control StudiesChinaCholesterol, HDL/blood/geneticsCholesterol, LDL/blood/geneticsCohort StudiesFasting/bloodGene Expression RegulationGenetic Predisposition to DiseaseGenome, Human*Genome-Wide Association StudyGenotyping TechniquesHumansJapanLinkage DisequilibriumMiddle AgedPhenotypePolymorphism, Single Nucleotide*Quantitative Trait LociRepublic of Korea
DOI
10.1038/ng.939
PMID
21909109
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Preventive Medicine & Public Health
AJOU Authors
조, 남한
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse