Evidence-based management and treatment of high-risk individuals with pre-diabetes

Abstract

The prevalence of type 2 diabetes (T2DM) has increased dramatically during the last decade, especially in Asian population. The control of hyperglycemia is very important for diabetes patients. Prevention of T2DM should be a major public health goal because of its substantial effect on heath. Treatment of high-risk individuals with impaired fasting glucose and impaired glucose tolerance to prevent T2DM has important medical, economic, social, and human implications. Identifying risk factors affecting transition diabetes is thus very important. Having defined a patient population at high-risk for developing diabetes, the intensive intervention of diet, physical activity, lifestyle modification, and drug therapy (metformin) can substantially affect the delay and prevention of T2DM. Tight glucose control has the potential to reduce the incidence and prevalence of T2DM.