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Non-invasive index for predicting significant liver fibrosis: comparison of diagnostic performances in patients with chronic hepatitis B and C

Authors
Cheong, JY; Um, SH; Seo, YS; Kim, DJ; Hwang, SG; Lee, YJ; Cho, M; Yang, JM; Kim, YB; Park, YN; Cho, SW
Citation
Digestive diseases and sciences, 56(2):555-563, 2011
Journal Title
Digestive diseases and sciences
ISSN
0163-21161573-2568
Abstract
BACKGROUND/AIMS: The majority of non-invasive markers of liver fibrosis have been developed in patients with chronic hepatitis C. We aimed to develop a formula for predicting significant fibrosis in patients with chronic viral hepatitis and to compare the usefulness of published models derived from the data obtained from patients with chronic hepatitis C.



METHODS: Serum markers and the METAVIR stage of fibrosis in liver biopsy specimens were compared prospectively in patients with chronic hepatitis B and C (estimation set, 367; validation set, 159).



RESULTS: In the estimation set, multiple forward stepwise logistic regression analysis identified γ-glutamyl transpeptidase, haptoglobin, α2-macroglobulin, matrix metalloproteinase-2, and tissue inhibitor of metalloproteinase-1 as independent predictors of significant fibrosis. A formula termed the SF index was constructed with the aforementioned five variables. The areas under the receiver operating characteristic curves of the SF index for predicting significant fibrosis were 0.828, 0.776, and 0.827 in the estimation, validation, and total sets, respectively. Using cut-off scores of 2.2 and 3.3, significant fibrosis was predicted with considerable accuracy. The diagnostic performances of the SF index and the Zeng index derived from chronic hepatitis B patients were much better than indices derived from chronic hepatitis C patients, such as the APRI, Forns index, and FIB-4.



CONCLUSIONS: We developed a novel formula for predicting significant fibrosis in patients with chronic viral hepatitis. Serum indices from studies in patients with chronic hepatitis C were less accurate in patients with chronic hepatitis B for predicting significant fibrosis.
MeSH terms
AdultBiological MarkersFemaleHepatitis B, Chronic/*complicationsHepatitis C, Chronic/*complicationsHumansLiver Cirrhosis/*etiologyMaleMiddle AgedPredictive Value of Tests
DOI
10.1007/s10620-010-1305-3
PMID
20585981
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
정, 재연김, 영배조, 성원
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