845. Metabolic Syndrome In Patients With Chronic Urticaria
Ye, Young-Min; Jin, Hyun-Jung; Hwang, Eui-Kyung; Nam, Young-Hee; Kim, Joo-Hee; Shin, Yoo-Seob; Park, Hae-Sim
Department of Allergy & Clinical Immunology, Ajou University School of Medicine
RATIONALE: An association between some inflammatory diseases and the metabolic syndrome (MetS) has been reported. Systemic pro-inflammatory and pro-coagulating state occurs in subjects with both chronic urticaria (CU) and MetS. This study was aimed to investigate the prevalence and clinical characteristics of metabolic syndrome in patients with CU.
METHODS: A hospital-based cross-sectional study on 131 CU patients (49 males and 82 females, mean age 40.5 years) was performed. MetS was diagnosed in the presence of three or more criteria of the NCEP ATP III (2001). The disease activity of CU was assessed by the UAS, a total score of 0–15. Serum CRP and TNF-α concentrations were measured by ELISA assay using commercially available reagents.
RESULTS: Thirty-two (27.1%) patients had a metabolic syndrome. CU patients with MetS were older, had a higher mean UAS and serum levels of ECP, TNF-α and complements, showed higher rate of negative ASST compared to those without metabolic syndrome. No significant correlations were found between the metabolic syndrome, and presence of auto-antibodies, disease duration, serum total IgE levels in CU patients. Logistic regression analysis indicated that a UAS of ≥13 (p=0.025) and presence of MetS (p=0.036) were significant and independent predictors of uncontrolled CU.
CONCLUSION: CU patients have a higher prevalence of MetS. TNF-α-associated systemic inflammation could be a common pathogenic mechanism of CU and metabolic syndrome. We suggest patients with severe and uncontrolled CU should be evaluated for MetS to correct cardiovascular risk factors as well as to improve CU outcomes.
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