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Norovirus infections in asymptomatic food handlers in elementary schools without norovirus outbreaks in some regions of Incheon, Korea.

Yu, JH; Kim, NY; Lee, EJ; Jeon, IS
Journal of Korean medical science, 26(6):734-739, 2011
Journal Title
Journal of Korean medical science
Norovirus (NV) has caused large outbreaks of gastroenteritis in schools. Studies of NV epidemiology in schools related to NV outbreaks have been frequently reported. However, reports of that in schools without outbreaks are not found. Presently, NV molecular epidemiology surveillance was carried out in asymptomatic food handlers working at nonoutbreak elementary schools in Incheon, Korea, in March, April and December, 2009. NV prevalence was examined by real-time reverse transcription-PCR (RT-PCR) and the positive products were re-evaluated by conventional RT-PCR for sequencing. Fecal samples (n = 776) were collected from 776 food handlers in 60 schools. NV was detected in 26 of them (3.4%). Of these, 17 (65%) were positive for NV GII and 10 (38%) were positive for NV GI. Of the 26 samples, 19 were positive by conventional RT-PCR. Sequencing of these 19 strains revealed GII/4 (n = 5), GI/6 (n = 3), GI/14 (n = 2), GII/8 (n = 2), GI/2 (n = 2), GI/10 (n = 1), GII/1 (n = 1), GII/3 (n = 1), GII/7 (n = 1), and GII/16 (n = 1). In this survey, the food handler population unrelated to NV outbreaks was found to normally contain asymptomatic carriers of NV. The excretion of NV from asymptomatic food handlers should be an infection source of NV outbreaks.
MeSH terms
AdultCaliciviridae Infections/*epidemiology/geneticsFeces/virologyFemaleFood HandlingGastroenteritis/*epidemiology/geneticsGenotypeHumansMaleMiddle AgedNorovirus/genetics/*isolation & purificationPrevalenceRNA, Viral/analysisRepublic of KoreaReverse Transcriptase Polymerase Chain ReactionSchoolsSequence Analysis, RNA
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Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
유, 준환
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