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The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes.
DC Field | Value | Language |
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dc.contributor.author | Han, SJ | - |
dc.contributor.author | Kang, ES | - |
dc.contributor.author | Kim, HJ | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Chun, SW | - |
dc.contributor.author | Ahn, CW | - |
dc.contributor.author | Cha, BS | - |
dc.contributor.author | Nam, M | - |
dc.contributor.author | Lee, HC | - |
dc.date.accessioned | 2010-12-17T02:10:37Z | - |
dc.date.available | 2010-12-17T02:10:37Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1096-7192 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/643 | - |
dc.description.abstract | OBJECTIVE: Atherosclerosis in patients with type 2 diabetes has been linked to oxidative stress. NADP[1]:quinone oxidoreductase 1 (NQO1) plays a key role in cellular antioxidant defense. Recent reports suggest that highly expressed and inducible endogenous NQO1 from cardiovascular cells may act as a potential superoxide scavenger. We examined the relationship between the risk of NQO1 C609T polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes.
METHODS: We recruited 601 (Seoul set) and 233 (Koyang set) unrelated patients with type 2 diabetes from independent groups. The C609T variant of NQO1 was genotyped by Taqman RT-PCR. Mean and maximum carotid intima-media thickness (IMT) and carotid artery plaques were measured by high-resolution ultrasonography. RESULTS: Patients with the T allele exhibited a higher prevalence of atherosclerotic plaques than non-T allele carriers in both sets (Seoul set vs. Koyang set, p=0.021, p=0.023, respectively). After adjusting for age, sex, duration of diabetes, systolic blood pressure, body mass index, current smoking, HDL-cholesterol, LDL-cholesterol and HbA1c, subjects with the T allele had a significantly higher risk of carotid artery plaques (Seoul set vs. Koyang set, OR=1.65, p=0.015; OR=2.00, p=0.037, respectively) than subjects with the CC genotype. CONCLUSION: These results suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients. | - |
dc.language.iso | en | - |
dc.subject.MESH | Carotid Artery, Common | - |
dc.subject.MESH | Carotid Stenosis | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Frequency | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | NAD(P)H Dehydrogenase (Quinone) | - |
dc.subject.MESH | Polymorphism, Single Nucleotide | - |
dc.subject.MESH | Tunica Intima | - |
dc.subject.MESH | Tunica Media | - |
dc.title | The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes. | - |
dc.type | Article | - |
dc.identifier.pmid | 19251446 | - |
dc.identifier.url | http://linkinghub.elsevier.com/retrieve/pii/S1096-7192(09)00032-8 | - |
dc.contributor.affiliatedAuthor | 한, 승진 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1016/j.ymgme.2009.01.012 | - |
dc.citation.title | Molecular genetics and metabolism | - |
dc.citation.volume | 97 | - |
dc.citation.number | 1 | - |
dc.citation.date | 2009 | - |
dc.citation.startPage | 85 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | Molecular genetics and metabolism, 97(1). : 85-90, 2009 | - |
dc.identifier.eissn | 1096-7206 | - |
dc.relation.journalid | J010967192 | - |
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