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The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes.

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dc.contributor.authorHan, SJ-
dc.contributor.authorKang, ES-
dc.contributor.authorKim, HJ-
dc.contributor.authorKim, SH-
dc.contributor.authorChun, SW-
dc.contributor.authorAhn, CW-
dc.contributor.authorCha, BS-
dc.contributor.authorNam, M-
dc.contributor.authorLee, HC-
dc.date.accessioned2010-12-17T02:10:37Z-
dc.date.available2010-12-17T02:10:37Z-
dc.date.issued2009-
dc.identifier.issn1096-7192-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/643-
dc.description.abstractOBJECTIVE: Atherosclerosis in patients with type 2 diabetes has been linked to oxidative stress. NADP[1]:quinone oxidoreductase 1 (NQO1) plays a key role in cellular antioxidant defense. Recent reports suggest that highly expressed and inducible endogenous NQO1 from cardiovascular cells may act as a potential superoxide scavenger. We examined the relationship between the risk of NQO1 C609T polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes.



METHODS: We recruited 601 (Seoul set) and 233 (Koyang set) unrelated patients with type 2 diabetes from independent groups. The C609T variant of NQO1 was genotyped by Taqman RT-PCR. Mean and maximum carotid intima-media thickness (IMT) and carotid artery plaques were measured by high-resolution ultrasonography.



RESULTS: Patients with the T allele exhibited a higher prevalence of atherosclerotic plaques than non-T allele carriers in both sets (Seoul set vs. Koyang set, p=0.021, p=0.023, respectively). After adjusting for age, sex, duration of diabetes, systolic blood pressure, body mass index, current smoking, HDL-cholesterol, LDL-cholesterol and HbA1c, subjects with the T allele had a significantly higher risk of carotid artery plaques (Seoul set vs. Koyang set, OR=1.65, p=0.015; OR=2.00, p=0.037, respectively) than subjects with the CC genotype.



CONCLUSION: These results suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients.
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dc.language.isoen-
dc.subject.MESHCarotid Artery, Common-
dc.subject.MESHCarotid Stenosis-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHFemale-
dc.subject.MESHGene Frequency-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNAD(P)H Dehydrogenase (Quinone)-
dc.subject.MESHPolymorphism, Single Nucleotide-
dc.subject.MESHTunica Intima-
dc.subject.MESHTunica Media-
dc.titleThe C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes.-
dc.typeArticle-
dc.identifier.pmid19251446-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1096-7192(09)00032-8-
dc.contributor.affiliatedAuthor한, 승진-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.ymgme.2009.01.012-
dc.citation.titleMolecular genetics and metabolism-
dc.citation.volume97-
dc.citation.number1-
dc.citation.date2009-
dc.citation.startPage85-
dc.citation.endPage90-
dc.identifier.bibliographicCitationMolecular genetics and metabolism, 97(1). : 85-90, 2009-
dc.identifier.eissn1096-7206-
dc.relation.journalidJ010967192-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
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