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Lymph node metastasis of gastric cancer is associated with the interaction between poly (ADP-ribose) polymerase 1 and matrix metallopeptidase 2.

Authors
Kim, J; Pyun, JA; Cho, SW; Lee, K; Kwack, K
Citation
DNA and cell biology, 30(12):1011-1017, 2011
Journal Title
DNA and cell biology
ISSN
1044-54981557-7430
Abstract
Poly (ADP-ribose) polymerase 1 (PARP1), which plays a critical role in the base excision DNA repair mechanism, and matrix metallopeptidase 2 (MMP2), a member of the matrix metalloprotease family, are involved in tumor formation and metastasis, respectively. In the present study, the possible association of single nucleotide polymorphisms (SNPs) and gene-gene interaction between PARP1 and MMP2 with the increased incidence of gastric cancer (GC) development and lymph node metastasis (LNM) was investigated in a Korean population. Samples were obtained from 326 patients with chronic gastritis and 153 patients with GC and genotyped using the GoldenGate® method. The PARP1 rs1136410 genotype showed a significant association with the frequency of LNM of GC (odds ratio [OR] = 2.19, p = 0.02), LNM stage (p = 0.035), and tumor invasion (p = 0.035). The allele frequency of MMP2 rs243865 was not associated with the development of GC or with the development of LNM of GC. Epistasis between the PARP1 SNP and the MMP2 SNP was associated with the development of LNM of GC. The combination of the MMP2 rs243865 CC genotype and the PARP1 rs1136410 CC or CC+CT genotypes showed a high risk of LNM of GC (OR = 2.47, p = 0.01; OR = 2.28, p = 0.01, respectively). In summary, PARP1 is associated with the risk of LNM of GC and the stage of LNM and tumor invasion. Epistasis between PARP1 rs1136410 and MMP2 rs243865 increased the risk of LNM of GC.
MeSH terms
AdultAgedAged, 80 and overAllelesCase-Control StudiesChronic Disease*Epistasis, GeneticFemaleGastritis/enzymology/geneticsGene FrequencyGenotypeHumansLymphatic Metastasis/*geneticsMaleMatrix Metalloproteinase 2/*geneticsMiddle AgedNeoplasm InvasivenessNeoplasm Proteins/*geneticsNeoplasm StagingPoly(ADP-ribose) Polymerases/*geneticsPolymorphism, Single NucleotideRepublic of Korea/epidemiologyStomach Neoplasms/enzymology/epidemiology/*genetics/pathology
DOI
10.1089/dna.2011.1250
PMID
21612407
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
조, 성원이, 광재
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