24 292

Cited 89 times in

Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome.

Authors
Kim, HC; Kim, DJ; Huh, KB
Citation
Atherosclerosis, 204(2):521-525, 2009
Journal Title
Atherosclerosis
ISSN
0021-91501879-1484
Abstract
OBJECTIVE: Controversy exists as to whether the association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis is independent of other metabolic disorders. We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS). METHODS: A cross-sectional analysis was performed among 556 men and 465 women, ages 30-79 years. The presence of NAFLD was evaluated ultrasonographically. Carotid IMT was determined ultrasonographically by the average of the maximal IMT at each common carotid artery. Independent associations between NAFLD and IMT were assessed using multiple linear and logistic regression models, after adjusting for age, sex, waist circumference, systolic blood pressure, fasting glucose, total/HDL-cholesterol ratio, smoking, and alcohol consumption. RESULTS: After adjusting for major risk factors, subjects with NAFLD had greater carotid IMT than subjects without NAFLD (difference 0.034 mm, p=0.016). However, the difference in IMT was significant only in subjects with MetS (0.060 mm, p=0.015) and not in subjects without MetS (0.015 mm, p=0.384). Similarly, the NAFLD-associated adjusted odds ratio for increased IMT, defined as the sex-specific top quintile, was 1.63 (95% CI, 1.10-2.42) in all subjects and 2.08 (95% CI, 1.19-3.66) in subjects with MetS, but 1.18 (95% CI, 0.64-2.19) in subjects without MetS. When the analysis was performed according to the number of metabolic abnormalities, the NAFLD-IMT association was observed only in subjects with four or more abnormalities. CONCLUSION: These results suggest that NAFLD is independently associated with carotid atherosclerosis only in people who have multiple metabolic abnormalities.
MeSH terms
AdultAgedCarotid Arteries/ultrasonography*Carotid Artery Diseases/epidemiology*Carotid Artery Diseases/ultrasonographyCross-Sectional StudiesFatty Liver/epidemiology*Fatty Liver/ultrasonographyFemaleHumansKorea/epidemiologyLinear ModelsLogistic ModelsMaleMetabolic Syndrome X/epidemiology*Middle AgedOdds RatioRisk AssessmentRisk FactorsTunica Intima/ultrasonography*Tunica Media/ultrasonography*
DOI
10.1016/j.atherosclerosis.2008.09.012
PMID
18947828
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
김대중
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse