16 215

Cited 16 times in

Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: insights from the Korea Acute Myocardial Infarction Registry.

Authors
Choi, CU; Rha, SW; Oh, DJ; Poddar, KL; Na, JO; Kim, JW; Lim, HE; Kim, EJ; Park, CG; Seo, HS; Hong, TJ; Park, JS; Kim, YJ; Hur, SH; Seong, IW; Chae, JK; Cho, MC; Bae, JH; Choi, DH; Jang, YS; Chae, IH; Kim, HS; Kim, CJ; Yoon, JH; Ahn, TH; Tahk, SJ; Chung, WS; Seung, KB; Chae, SC; Park, SJ; Ahn, YK; Jeong, MH
Citation
American heart journal, 161(2):373-382.e1-3, 2011
Journal Title
American heart journal
ISSN
0002-87031097-6744
Abstract
BACKGROUND: The optimal loading dose of clopidogrel in Asian patients with ST-segment elevation myocardial infarction (STEMI) has not been fully investigated. We compared bleeding, vascular complications, and midterm outcomes of a 300-mg versus a 600-mg loading dose of clopidogrel in a large series of Korean patients with STEMI undergoing primary percutaneous coronary intervention (PCI).



METHODS: A total of 2,664 STEMI patients (age 61.96 ± 11.91 years, men 70.4%) who underwent primary PCI were enrolled in this study. The patients were divided into a standard loading dose group (300 mg; n = 1,447 patients) and a high loading dose group (600 mg; n = 1,217 patients). Bleeding and vascular complications, and in-hospital and clinical outcomes up to 12 months were compared between the 2 groups.



RESULTS: In-hospital bleeding and vascular complications were similar between the 2 groups. There were no differences in bleeding and vascular complications and in 1- and 12-month clinical outcomes, including mortality, myocardial infarction, repeated PCI, and major adverse cardiac events, between the 2 groups. These findings were consistent even after the propensity score-matched analysis.



CONCLUSIONS: The standard loading dose of clopidogrel may be as safe and similarly effective as the high loading dose in Asian STEMI patients undergoing primary PCI.
MeSH terms
*Angioplasty, Balloon, CoronaryFemaleHumansMaleMiddle AgedMyocardial Infarction/physiopathology/*therapyPlatelet Aggregation Inhibitors/*administration & dosageRegistriesRepublic of KoreaRetrospective StudiesTiclopidine/administration & dosage/*analogs & derivatives
DOI
10.1016/j.ahj.2010.10.031
PMID
21315222
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
탁, 승제
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse