154 291

Cited 0 times in

High plasma interleukin-6 is associated with drug-eluting stent thrombosis: possible role of inflammatory cytokines in the development of stent thrombosis from the Korea Stent Thrombosis Registry.

Authors
Hwang, SJ; Park, KW; Kwon, DA; Kang, HJ; Koo, BK; Chae, IH; Gwon, HC; Park, SJ; Seung, KB; Ahn, T; Yoon, JH; Jang, YS; Jeong, MH; Tahk, SJ; Kim, HS
Citation
Circulation journal : official journal of the Japanese Circulation Society, 75(6):1350-1357, 2011
Journal Title
Circulation journal : official journal of the Japanese Circulation Society
ISSN
1346-98431347-4820
Abstract
BACKGROUND: Inflammation might contribute to the development of stent thrombosis (ST). The association between inflammatory cytokine concentrations and drug-eluting ST were evaluated.



METHODS AND RESULTS: Among the 123 ST patients enrolled in the multicenter Korea Stent Thrombosis registry, plasma samples were available in 41 patients. The patients' clinical characteristics and plasma concentrations of monocyte chemoattractant protein-1, tumor necrosis factor-alpha, and interleukin (IL)-6 were compared with 81 matched controls. Although the concentrations of 3 cytokines were higher in the ST group, they did not have significant differences. When divided into quartiles, the proportion of patients with the highest quartile of IL-6 was higher in the ST group than in the control group (44% vs. 16%, P = 0.001), and the highest IL-6 quartile was an independent predictor of ST for both early (adjusted hazard ratio [HR] 6.96; 95% confidence interval [CI] 1.75-27.66) and late ST (adjusted HR 4.71; 95%CI 1.06-20.92). In addition, the highest IL-6 quartile was an independent predictor of ST in those on clopidogrel (adjusted HR 7.70; 95%CI 1.97-30.13) but not in those who were off clopidogrel.



CONCLUSIONS: Highest IL-6 quartile was associated with ST, especially in clopidogrel users regardless of the time of ST, suggesting the involvement of inflammatory cytokines in ST.
MeSH terms
AgedAngioplasty, Balloon, Coronary/adverse effects/*instrumentationBiological Markers/bloodCase-Control StudiesChemokine CCL2/bloodChi-Square Distribution*Drug-Eluting StentsFemaleHumansInflammation Mediators/*bloodInterleukin-6/*bloodLogistic ModelsMaleMiddle AgedPlatelet Aggregation Inhibitors/therapeutic useProsthesis DesignRegistriesRepublic of KoreaRisk AssessmentRisk FactorsThrombosis/*immunologyTiclopidine/analogs & derivatives/therapeutic useTime FactorsTreatment OutcomeTumor Necrosis Factor-alpha/bloodUp-Regulation
PMID
21498913
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
탁, 승제
Full Text Link
Files in This Item:
1350-1357.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse