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Virtual histology intravascular ultrasound compared with optical coherence tomography for identification of thin-cap fibroatheroma.

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dc.contributor.authorKubo, T-
dc.contributor.authorNakamura, N-
dc.contributor.authorMatsuo, Y-
dc.contributor.authorOkumoto, Y-
dc.contributor.authorWu, X-
dc.contributor.authorChoi, SY-
dc.contributor.authorKomukai, K-
dc.contributor.authorTanimoto, T-
dc.contributor.authorIno, Y-
dc.contributor.authorKitabata, H-
dc.contributor.authorKimura, K-
dc.contributor.authorMizukoshi, M-
dc.contributor.authorImanishi, T-
dc.contributor.authorAkagi, H-
dc.contributor.authorYamamoto, T-
dc.contributor.authorAkasaka, T-
dc.date.accessioned2012-04-20T03:42:26Z-
dc.date.available2012-04-20T03:42:26Z-
dc.date.issued2011-
dc.identifier.issn1349-2365-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6455-
dc.description.abstractVirtual histology intravascular ultrasound (VH-IVUS) allows detailed assessment of plaque composition in the clinical setting. Optical coherence tomography (OCT) has been developed as a high-resolution imaging method, which might be a promising technique to identify thin-cap fibroatheroma (TCFA) in vivo. The purpose of the present study was to evaluate the diagnostic accuracy of VH-IVUS to identify TCFA as determined by OCT.We examined 96 target lesions in patients with stable angina pectoris by using VH-IVUS and OCT. VH-IVUS derived TCFA was defined as a focal necrotic core-rich lesion without evident overlying fibrous tissue. OCT derived TCFA was defined as a plaque with a fibrous cap of < 65 µm. VH-IVUS correctly identified 16 TCFA and 67 non-TCFA but misclassified 2 TCFA and 11 non-TCFA as determined by OCT. The sensitivity, specificity, and positive and negative predictive values of VH-IVUS to identify TCFA as determined by OCT were 89%, 86%, 59%, and 97%, respectively.VH-IVUS showed an acceptable sensitivity and specificity to identify TCFA as determined by OCT. Although the positive predictive value was low reflecting a high number of false positives, the negative predictive value was notably high. Our results suggest a potential role for VH-IVUS to exclude high risk lesions for future coronary events.-
dc.language.isoen-
dc.subject.MESHAged-
dc.subject.MESHAngina Pectoris/complications/*pathology/ultrasonography-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Vessels/*pathology/ultrasonography-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPlaque, Atherosclerotic/*diagnosis/ultrasonography-
dc.subject.MESH*Tomography, Optical Coherence-
dc.subject.MESH*Ultrasonography, Interventional-
dc.titleVirtual histology intravascular ultrasound compared with optical coherence tomography for identification of thin-cap fibroatheroma.-
dc.typeArticle-
dc.identifier.pmid21646741-
dc.identifier.urlhttp://joi.jlc.jst.go.jp/JST.JSTAGE/ihj/52.175?from=PubMed-
dc.contributor.affiliatedAuthor최, 소연-
dc.type.localJournal Papers-
dc.citation.titleInternational heart journal-
dc.citation.volume52-
dc.citation.number3-
dc.citation.date2011-
dc.citation.startPage175-
dc.citation.endPage179-
dc.identifier.bibliographicCitationInternational heart journal, 52(3):175-179, 2011-
dc.identifier.eissn1349-3299-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology

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