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Comparison of everolimus- and sirolimus-eluting stents in patients with long coronary artery lesions: a randomized LONG-DES-III (Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-III) Trial.

DC Field Value Language
dc.contributor.authorPark, DW-
dc.contributor.authorKim, YH-
dc.contributor.authorSong, HG-
dc.contributor.authorAhn, JM-
dc.contributor.authorKim, WJ-
dc.contributor.authorLee, JY-
dc.contributor.authorKang, SJ-
dc.contributor.authorLee, SW-
dc.contributor.authorLee, CW-
dc.contributor.authorPark, SW-
dc.contributor.authorYun, SC-
dc.contributor.authorSeung, KB-
dc.contributor.authorYang, TH-
dc.contributor.authorLee, SG-
dc.contributor.authorLee, JH-
dc.contributor.authorSeong, IW-
dc.contributor.authorCheong, SS-
dc.contributor.authorLee, BK-
dc.contributor.authorLee, NH-
dc.contributor.authorLee, K-
dc.contributor.authorKim, HS-
dc.contributor.authorJeon, DS-
dc.contributor.authorKim, MK-
dc.contributor.authorNah, DY-
dc.contributor.authorTahk, SJ-
dc.contributor.authorPark, SJ-
dc.date.accessioned2012-04-23-
dc.date.available2012-04-23-
dc.date.issued2011-
dc.identifier.issn1936-8798-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6471-
dc.description.abstractOBJECTIVES: This study compared everolimus-eluting stents (EES) and sirolimus-eluting stents (SES) for long coronary lesions.



BACKGROUND: Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments.



METHODS: This randomized, multicenter, prospective trial compared the use of long EES with SES in 450 patients with long (≥ 25 mm) native coronary lesions. The primary endpoint of the trial was in-segment late luminal loss at 9-month angiographic follow-up.



RESULTS: The EES and SES groups had similar baseline characteristics. Lesion length was 34.0 ± 15.4 mm in the EES group and 34.3 ± 13.5 mm in the SES group (p = 0.85). Nine-month angiographic follow-up was performed in 80% of the EES group and 81% of the SES group (p = 0.69). In-segment late loss as the primary study endpoint was significantly larger in the EES group than in the SES group (0.17 ± 0.41 mm vs. 0.09 ± 0.30 mm, p for noninferiority = 0.96, p for superiority = 0.04). The in-segment binary restenosis rate was also higher in the EES group than in the SES group (7.3% vs. 2.7%, p = 0.046). However, in-stent late loss (0.22 ± 0.43 mm vs. 0.18 ± 0.28 mm, p = 0.29) and in-stent binary restenosis rate (3.9% vs. 2.7%, p = 0.53) were similar among the 2 groups. The incidence of any clinical outcomes (death, myocardial infarction, stent thrombosis, target lesion revascularization, and composite outcomes) was not statistically different between the 2 groups.



CONCLUSIONS: For patients with long native coronary artery disease, EES implantation was associated with greater angiographic in-segment late loss and higher rates of in-segment restenosis compared with SES implantation. However, clinical outcomes were both excellent and not statistically different.
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dc.language.isoen-
dc.subject.MESHAngioplasty, Balloon, Coronary-
dc.subject.MESHCoronary Angiography-
dc.subject.MESHCoronary Restenosis-
dc.subject.MESHCoronary Vessels-
dc.subject.MESHDrug-Eluting Stents-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRecurrence-
dc.subject.MESHSirolimus-
dc.subject.MESHStatistics as Topic-
dc.subject.MESHTime Factors-
dc.titleComparison of everolimus- and sirolimus-eluting stents in patients with long coronary artery lesions: a randomized LONG-DES-III (Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-III) Trial.-
dc.typeArticle-
dc.identifier.pmid22017935-
dc.identifier.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1936-8798(11)00569-3-
dc.contributor.affiliatedAuthor탁, 승제-
dc.type.localJournal Papers-
dc.identifier.doi10.1016/j.jcin.2011.05.024-
dc.citation.titleJACC. Cardiovascular interventions-
dc.citation.volume4-
dc.citation.number10-
dc.citation.date2011-
dc.citation.startPage1096-
dc.citation.endPage1103-
dc.identifier.bibliographicCitationJACC. Cardiovascular interventions, 4(10). : 1096-1103, 2011-
dc.identifier.eissn1876-7605-
dc.relation.journalidJ019368798-
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Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
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