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Predictors of pulmonary function response to treatment with salmeterol/fluticasone in patients with chronic obstructive pulmonary disease.

Authors
Lee, JS; Huh, JW; Chae, EJ; Seo, JB; Ra, SW; Lee, JH; Kim, EK; Lee, YK; Kim, TH; Kim, WJ; Lee, SM; Lee, S; Lim, SY; Shin, TR; Yoon, HI; Sheen, SS; Oh, YM; Lee, SD
Citation
Journal of Korean medical science, 26(3):379-385, 2011
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and responses to therapies are highly variable. The aim of this study was to identify the predictors of pulmonary function response to 3 months of treatment with salmeterol/fluticasone in patients with COPD. A total of 127 patients with stable COPD from the Korean Obstructive Lung Disease (KOLD) Cohort, which were prospectively recruited from June 2005 to September 2009, were analyzed retrospectively. The prediction models for the FEV(1), FVC and IC/TLC changes after 3 months of treatment with salmeterol/fluticasone were constructed by using multiple, stepwise, linear regression analysis. The prediction model for the FEV(1) change after 3 months of treatment included wheezing history, pre-bronchodilator FEV(1), post-bronchodilator FEV(1) change and emphysema extent on CT (R = 0.578). The prediction models for the FVC change after 3 months of treatment included pre-bronchodilator FVC, post-bronchodilator FVC change (R = 0.533), and those of IC/ TLC change after 3 months of treatment did pre-bronchodilator IC/TLC and post-bronchodilator FEV(1) change (R = 0.401). Wheezing history, pre-bronchodilator pulmonary function, bronchodilator responsiveness, and emphysema extent may be used for predicting the pulmonary function response to 3 months of treatment with salmeterol/fluticasone in patients with COPD.
MeSH terms
AgedAlbuterol/*analogs & derivatives/therapeutic useAndrostadienes/*therapeutic useBronchodilator Agents/*therapeutic useEmphysemaFemaleHumansLinear ModelsLung/physiopathologyMaleMiddle AgedPrognosisPulmonary Disease, Chronic Obstructive/*drug therapyRepublic of KoreaRespiratory Function TestsRetrospective StudiesTomography Scanners, X-Ray ComputedTreatment Outcome
DOI
10.3346/jkms.2011.26.3.379
PMID
21394306
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
AJOU Authors
신, 승수
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