68 456

Cited 12 times in

Different therapeutic responses in chronic obstructive pulmonary disease subgroups.

Authors
Lee, JS; Huh, JW; Chae, EJ; Seo, JB; Ra, SW; Lee, JH; Kim, EK; Lee, YK; Kim, TH; Kim, WJ; Lee, SM; Lee, S; Lim, SY; Shin, TR; Yoon, HI; Sheen, SS; Oh, YM; Lee, SD
Citation
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 15(8):1104-1110, 2011
Journal Title
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
ISSN
1027-37191815-7920
Abstract
SETTING: Eleven referring hospitals in South Korea.



OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classified by diffusing capacity of the lung for carbon monoxide (DL(CO)) and lung volume.



DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DL(CO) and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting β(2)-agonist (SABA) and 3-month combined inhalation of long-acting β(2)-agonist (LABA) and corticosteroid among patients with these subgroups.



RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DL(CO) and RV/TLC, 28 (21.5%) low DL(CO) and normal RV/TLC, 31 (23.8%) normal DL(CO) and high RV/TLC, and 30 (23.1%) low DL(CO) and high RV/TLC. The normal DL(CO)/high RV/TLC subgroup showed a significantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DL(CO)/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DL(CO)/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups.



CONCLUSION: COPD subgroups classified by DL(CO) and RV/TLC may have different pulmonary function responses to pharmacological treatment.
MeSH terms
Administration, InhalationAdrenal Cortex Hormones/*administration & dosageAdrenergic beta-2 Receptor Agonists/*administration & dosageAgedBronchodilator Agents/*administration & dosageChi-Square DistributionHumansLung/*drug effects/physiopathology/radiographyLung Volume MeasurementsMaleMiddle AgedPredictive Value of TestsPulmonary Diffusing CapacityPulmonary Disease, Chronic Obstructive/classification/diagnosis/*drug therapy/physiopathologyRepublic of KoreaResidual VolumeRetrospective StudiesTomography, X-Ray ComputedTotal Lung CapacityTreatment Outcome
DOI
10.5588/ijtld.10.0553
PMID
21740676
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
AJOU Authors
신, 승수
Full Text Link
Files in This Item:
21740676.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse