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MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome.

Authors
Y, Cámara; J, Asin-Cayuela; CB, Park; MD, Metodiev; Y, Shi; B, Ruzzenente; C, Kukat; B, Habermann; R, Wibom; K, Hultenby; T, Franz; H, Erdjument-Bromage; P, Tempst; BM, Hallberg; CM, Gustafsson; NG, Larsson
Citation
Cell metabolism, 13(5):527-539, 2011
Journal Title
Cell metabolism
ISSN
1550-41311932-7420
Abstract
Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria.
MeSH terms
AnimalsBlotting, NorthernCardiomyopathiesCarrier Proteins/genetics/*metabolismDNA, Mitochondrial/genetics*Gene Expression Regulation, DevelopmentalImmunoprecipitationIntegrases/metabolismMethyltransferasesMiceMice, KnockoutMitochondria/*genetics/*metabolismMitochondrial Diseases/genetics/pathologyOxidative Phosphorylation*Protein BiosynthesisProtein Methyltransferases/*metabolismRNA, Ribosomal/geneticsRibosomal Proteins/*physiologyRibosomes/*metabolismSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTranscription Factors/geneticsTranscription, Genetic
DOI
10.1016/j.cmet.2011.04.002
PMID
21531335
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
박, 찬배
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