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Mitochondrial DNA mutations in disease and aging.

Authors
CB, Park; NG, Larsson
Citation
The Journal of cell biology, 193(5):809-818, 2011
Journal Title
The Journal of cell biology
ISSN
0021-95251540-8140
Abstract
The small mammalian mitochondrial DNA (mtDNA) is very gene dense and encodes factors critical for oxidative phosphorylation. Mutations of mtDNA cause a variety of human mitochondrial diseases and are also heavily implicated in age-associated disease and aging. There has been considerable progress in our understanding of the role for mtDNA mutations in human pathology during the last two decades, but important mechanisms in mitochondrial genetics remain to be explained at the molecular level. In addition, mounting evidence suggests that most mtDNA mutations may be generated by replication errors and not by accumulated damage.
MeSH terms
Aging/*geneticsAnimalsDNA Replication/geneticsDNA, Mitochondrial/*geneticsDisease/*geneticsHumansMutation/*genetics
DOI
10.1083/jcb.201010024
PMID
21606204
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
AJOU Authors
박, 찬배
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