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Carotid atheromatic plaque is commonly associated with hypopituitary men.

Authors
Kim, JY; Hong, JW; Rhee, SY; Kim, CS; Kim, DJ; Lee, EJ
Citation
Pituitary, 14(2):105-111, 2011
Journal Title
Pituitary
ISSN
1386-341X1573-7403
Abstract
Hypopituitarism increases the risks of many cardiovascular conditions and therefore, patients with this disease are more prone to cardiovascular disease. To our knowledge, there have been few studies on carotid artery plaque in male patients with hypopituitarism in assessing cardiovascular risks. The aim of this study was to specifically compare carotid artery plaque while examining other major cardiovascular risk factors between male patients with hypopituitarism and control subjects. Forty male patients aged 30-70 years with hypopituitarism and forty age, sex- matched control subjects were recruited at the Yonsei University Severance Hospital, Seoul, Korea. Carotid intima media thickness (IMT) and atheromatous plaque, anthropometry, lipid profile, and pituitary hormones were assessed. Atheromatous plaque in the carotid arteries was observed more frequently in patients with hypopituitarism than age- and sex-matched control subjects (59.5% vs. 2.5%, P<0.01) without differences of carotid IMTs. Patients with hypopituitarism also exhibited higher waist circumference, waist to hip ratio, total cholesterol and LDL cholesterol than control subjects. In subgroup analysis in male patients with hypopituitarism including GH deficiency, lower testosterone levels were associated with higher waist circumference (r=0.446, P=0.033). In conclusion, hypopituitary males exhibit an increased incidence of carotid artery plaque without differences of carotid IMTs, central obesity and higher total cholesterol level. Lower testosterone levels were associated with central obesity- a strong component of a metabolic syndrome, and unsubstituted testosterone deficiency might be an important cardiovascular risk factor in patients with hypopituitarism.
MeSH terms
Adenoma/complications/epidemiologyAdultAgedCarotid Artery Diseases/complications/*epidemiologyCase-Control StudiesComorbidityHumansHypopituitarism/complications/*epidemiologyMaleMiddle AgedPituitary Neoplasms/complications/epidemiologyPlaque, Atherosclerotic/complications/*epidemiologyTestosterone/bloodWaist Circumference/physiology
DOI
10.1007/s11102-010-0265-0
PMID
20981493
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
김, 대중
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