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Bax predicts outcome in gastric cancer patients treated with 5-fluorouracil, leucovorin, and oxaliplatin palliative chemotherapy.

DC Field Value Language
dc.contributor.authorJeong, SH-
dc.contributor.authorHan, JH-
dc.contributor.authorKim, JH-
dc.contributor.authorAhn, MS-
dc.contributor.authorHwang, YH-
dc.contributor.authorLee, HW-
dc.contributor.authorKang, SY-
dc.contributor.authorPark, JS-
dc.contributor.authorChoi, JH-
dc.contributor.authorLee, KJ-
dc.contributor.authorSheen, SS-
dc.contributor.authorLim, HY-
dc.date.accessioned2012-04-23T23:55:15Z-
dc.date.available2012-04-23T23:55:15Z-
dc.date.issued2011-
dc.identifier.issn0163-2116-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6508-
dc.description.abstractBACKGROUND: Platinum and 5-fluorouracil (5-FU)-based regimens have been used the most frequently in palliative chemotherapy for gastric cancer. The present study evaluated the prognostic significance of Bax, excision repair cross-complementation group 1 (ERCC1), and thymidylate synthase (TS) in advanced gastric cancer patients treated with 5-FU, leucovorin, and oxaliplatin (FOLFOX) palliative chemotherapy.



METHODS: Seventy-two patients with metastatic or recurrent gastric cancer were treated with FOLFOX regimen. Pretreatment tumor biopsy specimens were analyzed for Bax, ERCC1, and TS expression by immunohistochemistry.



RESULTS: High expression of Bax, ERCC1, and TS was observed in 31 (43%), 33 (46%), and 35 (49%) patients, respectively. The median overall survival (OS) of patients was 12 months. Low expression of Bax was associated with poor OS (median, 9 months vs. 18 months; 2-year, 10% vs. 48%; p=0.0005) in univariate analysis, while expression of ERCC1 and TS was not correlated with patient outcome. In multivariate analysis, low expression of Bax was a significant independent predictor of poor OS (p=0.028). Low expression of Bax was significantly associated with poor survival of patients with metastatic or recurrent gastric cancer treated with FOLFOX chemotherapy.



CONCLUSIONS: Immunohistochemical staining for Bax with pretreatment biopsy specimen may be useful in selecting FOLFOX regimen as a treatment option for advanced gastric cancer patients.
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dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols-
dc.subject.MESHBiopsy-
dc.subject.MESHDNA-Binding Proteins-
dc.subject.MESHEndonucleases-
dc.subject.MESHFemale-
dc.subject.MESHFluorouracil-
dc.subject.MESHHumans-
dc.subject.MESHLeucovorin-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrganoplatinum Compounds-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStomach-
dc.subject.MESHStomach Neoplasms-
dc.subject.MESHThymidylate Synthase-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTumor Markers, Biological-
dc.subject.MESHbcl-2-Associated X Protein-
dc.titleBax predicts outcome in gastric cancer patients treated with 5-fluorouracil, leucovorin, and oxaliplatin palliative chemotherapy.-
dc.typeArticle-
dc.identifier.pmid20503071-
dc.contributor.affiliatedAuthor정, 성현-
dc.contributor.affiliatedAuthor한, 재호-
dc.contributor.affiliatedAuthor김, 장희-
dc.contributor.affiliatedAuthor안, 미선-
dc.contributor.affiliatedAuthor이, 현우-
dc.contributor.affiliatedAuthor강, 석윤-
dc.contributor.affiliatedAuthor박, 준성-
dc.contributor.affiliatedAuthor최, 진혁-
dc.contributor.affiliatedAuthor이, 광재-
dc.contributor.affiliatedAuthor신, 승수-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s10620-010-1280-8-
dc.citation.titleDigestive diseases and sciences-
dc.citation.volume56-
dc.citation.number1-
dc.citation.date2011-
dc.citation.startPage131-
dc.citation.endPage138-
dc.identifier.bibliographicCitationDigestive diseases and sciences, 56(1). : 131-138, 2011-
dc.identifier.eissn1573-2568-
dc.relation.journalidJ001632116-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
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