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Trough plasma imatinib levels are correlated with optimal cytogenetic responses at 6 months after treatment with standard dose of imatinib in newly diagnosed chronic myeloid leukemia.

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dc.contributor.authorSohn, SK-
dc.contributor.authorOh, SJ-
dc.contributor.authorKim, BS-
dc.contributor.authorRyoo, HM-
dc.contributor.authorChung, JS-
dc.contributor.authorJoo, YD-
dc.contributor.authorBang, SM-
dc.contributor.authorJung, CW-
dc.contributor.authorKim, DH-
dc.contributor.authorYoon, SS-
dc.contributor.authorKim, H-
dc.contributor.authorLee, HG-
dc.contributor.authorWon, JH-
dc.contributor.authorMin, YH-
dc.contributor.authorCheong, JW-
dc.contributor.authorPark, JS-
dc.contributor.authorEom, KS-
dc.contributor.authorHyun, MS-
dc.contributor.authorKim, MK-
dc.contributor.authorPark, MR-
dc.contributor.authorPark, J-
dc.contributor.authorKim, CS-
dc.contributor.authorKim, HJ-
dc.contributor.authorKim, YK-
dc.contributor.authorPark, EK-
dc.contributor.authorZang, DY-
dc.contributor.authorJo, DY-
dc.contributor.authorMoon, JH-
dc.contributor.authorPark, SY-
dc.date.accessioned2012-04-24-
dc.date.available2012-04-24-
dc.date.issued2011-
dc.identifier.issn1042-8194-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6511-
dc.description.abstractTo investigate the correlation of trough imatinib mesylate (IM) levels with cytogenetic or molecular responses, we measured trough IM levels in patients with chronic myeloid leukemia, chronic phase (CML-CP), at 6 months of treatment with a standard dose of IM. Eighty-seven newly diagnosed patients with CML-CP were prospectively enrolled. Seventy-eight patients (89.7%) showed an optimal response (complete or partial cytogenetic response) at 6 months. Trough IM levels were 1378 ± 725 ng/mL. When categorized into two groups, there was a statistically significant difference in numbers of patients with optimal and suboptimal responses at 6 months (group with  <1000: 80.6% vs. 19.4%;  ≥ 1000: 94.6% vs. 5.4%; p = 0.032), and in numbers of patients with early major molecular response (early-MMR) and without MMR at 6 months (group with  <1000: 3.2% vs. 96.8%;  ≥ 1000: 21.4% vs. 78.6%; p = 0.047). In conclusion, the incidence of optimal cytogenetic response or early-MMR in patients with CML-CP treated with IM for 6 months was significantly higher in those with a trough level of  ≥ 1000 compared with those with a level of <1000. Dose escalation of IM can be one option in patients with CML showing suboptimal response or resistance to the standard dose of IM, especially with low trough plasma IM levels (<1000 ng/mL).-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Agents-
dc.subject.MESHFemale-
dc.subject.MESHFusion Proteins, bcr-abl-
dc.subject.MESHHumans-
dc.subject.MESHLeukemia, Myeloid, Chronic-Phase-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHNeutropenia-
dc.subject.MESHPiperazines-
dc.subject.MESHProspective Studies-
dc.subject.MESHPyrimidines-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHThrombocytopenia-
dc.subject.MESHTime Factors-
dc.subject.MESHTranscription, Genetic-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleTrough plasma imatinib levels are correlated with optimal cytogenetic responses at 6 months after treatment with standard dose of imatinib in newly diagnosed chronic myeloid leukemia.-
dc.typeArticle-
dc.identifier.pmid21463107-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.3109/10428194.2011.563885-
dc.contributor.affiliatedAuthor박, 준성-
dc.type.localJournal Papers-
dc.identifier.doi10.3109/10428194.2011.563885-
dc.citation.titleLeukemia & lymphoma-
dc.citation.volume52-
dc.citation.number6-
dc.citation.date2011-
dc.citation.startPage1024-
dc.citation.endPage1029-
dc.identifier.bibliographicCitationLeukemia & lymphoma, 52(6). : 1024-1029, 2011-
dc.identifier.eissn1029-2403-
dc.relation.journalidJ010428194-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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