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Lymphopenia is an important prognostic factor in peripheral T-cell lymphoma (NOS) treated with anthracycline-containing chemotherapy.

Authors
Kim, YR; Kim, JS; Kim, SJ; Jung, HA; Kim, WS; Lee, HW; Eom, HS; Jeong, SH; Park, JS; Cheong, JW; Min, YH
Citation
Journal of hematology & oncology, 4:34-34, 2011
Journal Title
Journal of hematology & oncology
ISSN
1756-8722
Abstract
BACKGROUND: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with poor treatment outcomes. The aim of this study was to evaluate whether lymphopenia at diagnosis would have an adverse effect on survival in patients with PTCL-NOS treated with anthracycline-containing chemotherapy.



METHODS: A total of 118 patients with PTCL-NOS treated with anthracycline-containing chemotherapy from 4 Korean institutions were included.



RESULTS: Thirty-six patients (30.5%) had a low absolute lymphocyte count (ALC, < 1.0 × 109/L) at diagnosis. Patients with lymphopenia had shorter overall survival (OS) and progression-free survival (PFS) rates compared with patients with high ALCs (P = 0.003, P = 0.012, respectively). In multivariate analysis, high-intermediate/high-risk International Prognostic Index (IPI) scores and lymphopenia were both associated with shorter OS and PFS. Treatment-related mortality was 25.0% in the low ALC group and 4.8% in the high ALC group (P = 0.003). In patients considered high-intermediate/high-risk based on IPI scores, lymphopenia was also associated with shorter OS and PFS (P = 0.002, P = 0.001, respectively).



CONCLUSION: This study suggests that lymphopenia could be an independent prognostic marker to predict unfavorable OS and PFS in patients with PTCL-NOS treated with anthracycline-containing chemotherapy and can be used to further stratify high-risk patients using IPI scores.
MeSH terms
AdultAgedAged, 80 and overAnthracyclines/*therapeutic useAntineoplastic Agents/*therapeutic useDisease-Free SurvivalFemaleHumansLymphocyte CountLymphoma, T-Cell, Peripheral/complications/*diagnosis/*drug therapyLymphopenia/*complicationsMaleMiddle AgedPrognosisRepublic of KoreaTreatment OutcomeYoung Adult
DOI
10.1186/1756-8722-4-34
PMID
21843362
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
AJOU Authors
정, 성현박, 준성
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