111 209

Cited 30 times in

The outcomes of using colistin for treating multidrug resistant Acinetobacter species bloodstream infections.

Authors
Lim, SK; Lee, SO; Choi, SH; Choi, JP; Kim, SH; Jeong, JY; Woo, JH; Kim, YS
Citation
Journal of Korean medical science, 26(3):325-331, 2011
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Despite the identification of Acinetobacter baumannii isolates that demonstrate susceptibility to only colistin, this antimicrobial agent was not available in Korea until 2006. The present study examined the outcomes of patients with multidrug resistant (MDR) Acinetobacter species bloodstream infection and who were treated with or without colistin as part of their regimen. The colistin group was given colistin as part of therapy once colistin became available in 2006. The non-colistin group was derived from the patients who were treated with other antimicrobial regimens before 2006. Mortality within 30 days of the onset of bacteremia occurred for 11 of 31 patients in the colistin group and for 15 of 39 patients in the non-colistin group (35.5% vs 38.5%, respectively, P = 0.80). Renal dysfunction developed in 50.0% of the 20 evaluable patients in the colistin group, but in 28.6% of the 35 evaluable patients in the non-colistin group (P = 0.11). On multivariate analysis, only an Acute Physiological and Chronic Health Evaluation II score ≥ 21 was associated with mortality at 30 days. This result suggests that administering colistin, although it is the sole microbiologically appropriate agent, does not influence the 30 day mortality of patients with a MDR Acinetobacter spp. bloodstream infection.
MeSH terms
APACHEAcinetobacter/*drug effects/isolation & purificationAcinetobacter Infections/*drug therapy/mortalityAdolescentAdultAgedAged, 80 and overAnti-Bacterial Agents/*therapeutic useBacteremia/*drug therapy/mortalityChildColistin/administration & dosage/*therapeutic useDrug Resistance, Multiple, Bacterial/*drug effectsFemaleHumansMaleMiddle AgedRepublic of KoreaRetrospective StudiesRiskTreatment Outcome
DOI
10.3346/jkms.2011.26.3.325
PMID
21394298
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
AJOU Authors
임, 승관
Full Text Link
Files in This Item:
325-331.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse