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A case of piperacillin-induced occupational anaphylaxis: detection of serum IgE to piperacillin-HSA conjugate.

Authors
Kim, JE; Kim, SH; Kim, JH; Bahn, JW; Jin, HJ; Ye, YM; Park, HS
Citation
Journal of Korean medical science, 26(5):682-685, 2011
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
This is the first reported detection of serum IgE antibody to piperacillin-human serum albumin (HSA) conjugate in a patient presenting with anaphylaxis that developed after occupational exposure. A 24-yr-old nurse, who had worked at a University Hospital for 2 yr, experienced chest tightness, dizziness, generalized urticaria, abdominal pain, and diarrhea 10 min after administering a piperacillin injection. She had previously suffered from atopic dermatitis. A skin prick test for common inhalant allergens was entirely negative; in contrast, her serum total IgE was elevated (283 IU/mL). A high level of piperacillin-specific serum IgE was detected by ELISA using piperacillin-HSA conjugate. Significant inhibition upon addition of both free piperacillin and piperacillin-HSA conjugate was detected by inhibition ELISA. These data suggest that piperacillin exposure in the workplace can induce occupational anaphylaxis and urticaria mediated by an interaction of IgE with the hapten of piperacillin.
MeSH terms
Anaphylaxis/*chemically induced/immunologyEnzyme-Linked Immunosorbent AssayFemaleHospitals, UniversityHumansImmunoglobulin E/*blood/immunologyIntensive Care UnitsOccupational Diseases/*chemically induced/immunology*Occupational ExposurePiperacillin/*immunologySerum Albumin/*immunologyUrticaria/immunologyYoung Adult
DOI
10.3346/jkms.2011.26.5.682
PMID
21532862
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 승현진, 현정예, 영민박, 해심
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