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Association of β₂-adrenergic receptor polymorphism with work-related symptoms in workers exposed to wheat flour.

Authors
Hur, GY; Park, HJ; Lee, HY; Koh, DH; Lee, BJ; Choi, GS; Kim, SH; Ye, YM; Park, HS
Citation
Yonsei medical journal, 52(3):488-494, 2011
Journal Title
Yonsei medical journal
ISSN
0513-57961976-2437
Abstract
PURPOSE: Our previous study indicated that the presence of wheat-specific IgG1 and IgG4 antibodies was associated with work-related symptoms in workers exposed to wheat flour. We performed this study to investigate the genetic polymorphisms of β₂-adrenergic receptors and wheat-specific antibodies in association with the clinical parameters of baker's asthma.



MATERIALS AND METHODS: In total, 379 subjects working in a single industrial bakery were enrolled in this study. The skin prick test was performed with common inhalant allergens and wheat flour extract. The presence of serum- specific IgE, IgG1, and IgG4 antibodies to wheat flour were determined by ELISA. Whole blood samples were obtained for genotype analysis. Subjects were genotyped with regard to five candidate single nucleotide polymorphisms (SNPs) of the β₂-adrenergic receptor gene (ADRB2; -47 T>C, 46 A>G, 79 C>G, 252 G>A, and 523 C>A) using a single-base extension method.



RESULTS: No significant associations were observed between the genotype/allele frequencies of any of the SNPs tested and any clinical parameters. The haplotype of ADRB2 (GAA composed of 46 A>G, 252 G>A, and 523 C>A) was significantly associated with work-related symptoms (pG and haplotype [GAA] of ADRB2, the prevalence rates of wheat-specific IgG1 antibodies and lower respiratory symptoms increased significantly with exposure intensity (both p<0.05).



CONCLUSION: The findings of the present study suggest that ADRB2 genetic polymorphism may contribute to the development of work-related symptoms in workers exposed to wheat flour, which can lead to baker's asthma.
MeSH terms
AdultAllergens/*immunologyAsthma/genetics/*immunologyEnzyme-Linked Immunosorbent AssayFemale*FlourHaplotypesHumansImmunoglobulin G/immunologyInhalation Exposure/analysisMaleOccupational Exposure/analysis*Polymorphism, GeneticPolymorphism, Single NucleotideReceptors, Adrenergic, beta-2/*geneticsSkin TestsTriticum/*immunology
DOI
10.3349/ymj.2011.52.3.488
PMID
21488193
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 승현예, 영민박, 해심
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