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Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia.
DC Field | Value | Language |
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dc.contributor.author | Kim, B | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Yang, MS | - |
dc.contributor.author | Jou, I | - |
dc.contributor.author | Joe, EH | - |
dc.date.accessioned | 2010-12-17T03:02:12Z | - |
dc.date.available | 2010-12-17T03:02:12Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0360-4012 | - |
dc.identifier.uri | http://repository.ajou.ac.kr/handle/201003/652 | - |
dc.description.abstract | Retinoic acid (RA) is a well-known antiinflammatory agent. In this study, we show that RA has a dual effect on cyclooxygenase-2 (COX-2) expression in inflammatory activated microglia, the resident brain macrophages. After treatment of microglia with LPS or thrombin, COX-2 expression was induced in two phases, specifically, an initial increase at about 12 hr after stimulation followed by a decrease, and another increase at about 48-72 hr. However, PGE(2) and 15d-PGJ(2) were detected at about 12 hr, and the levels continuously increased thereafter. Interestingly, all-trans retinoic acid (ATRA) suppressed the expression of early-phase COX-2 but augmented late-phase COX-2 and inhibited iNOS in the whole time sequence. ATRA enhanced PGE(2) production but had little effect on 15d-PGJ(2). Moreover, ATRA selectively up-regulated the expression of a PGE(2) synthase, mPGES-1, but had little effect on the PGD(2) synthase, H-PGDS. The results collectively suggest that ATRA modulates microglial responses to inflammatory stimulators, particularly at the late phase, via enhancement of COX-2 expression and PGE(2) production. | - |
dc.language.iso | en | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Brain | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cyclooxygenase 2 | - |
dc.subject.MESH | Dinoprostone | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Inflammation | - |
dc.subject.MESH | Intramolecular Oxidoreductases | - |
dc.subject.MESH | Lipopolysaccharides | - |
dc.subject.MESH | Microglia | - |
dc.subject.MESH | Microsomes | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Thrombin | - |
dc.subject.MESH | Tretinoin | - |
dc.title | Retinoic acid enhances prostaglandin E2 production through increased expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in rat brain microglia. | - |
dc.type | Article | - |
dc.identifier.pmid | 18183617 | - |
dc.contributor.affiliatedAuthor | 주, 일로 | - |
dc.contributor.affiliatedAuthor | 조, 은혜 | - |
dc.type.local | Journal Papers | - |
dc.identifier.doi | 10.1002/jnr.21593 | - |
dc.citation.title | Journal of neuroscience research | - |
dc.citation.volume | 86 | - |
dc.citation.number | 6 | - |
dc.citation.date | 2008 | - |
dc.citation.startPage | 1353 | - |
dc.citation.endPage | 1360 | - |
dc.identifier.bibliographicCitation | Journal of neuroscience research, 86(6). : 1353-1360, 2008 | - |
dc.identifier.eissn | 1097-4547 | - |
dc.relation.journalid | J003604012 | - |
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