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Microglial P2X₇ receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease.

Authors
Lee, HG; Won, SM; Gwag, BJ; Lee, YB
Citation
Experimental & molecular medicine, 43(1):7-14, 2011
Journal Title
Experimental & molecular medicine
ISSN
1226-36132092-6413
Abstract
The possibility that P2X₇ receptor (P2X₇R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APPswe/PS1dE9 mouse model of Alzheimer's disease (AD). P2X7R was predominantly expressed in CD11b-immunopositive microglia from 3 months of age before Abeta plaque formation. In addition, gp91phox, a catalytic subunit of NADPH oxidase, and ethidium fluorescence were detected in P2X₇R-positive microglial cells of animals at 6 months of age, indicating that P2X₇R-positive microglia could produce ROS. Postsynaptic density 95-positive dendrites showed significant damage in regions positive for P2X₇R in the cerebral cortex of 6 month-old mice. Taken together, up-regulation of P2X₇R activation and ROS production in microglia are parallel with Aβ increase and correlate with synaptotoxicity in AD.
MeSH terms
Aging*Alzheimer Disease/genetics/metabolism/pathologyAmyloid beta-PeptidesAnimalsAntigens, CD11b/immunologyBlotting, WesternCerebral Cortex/metabolism/*pathologyDisease Models, AnimalGene ExpressionMiceMice, TransgenicMicroglia/*metabolism/pathologyNeurons/metabolism/*pathologyPlaque, AmyloidReactive Oxygen Species/*metabolismReceptors, Immunologic/analysisReceptors, Purinergic P2X7/*genetics/metabolism
DOI
10.3858/emm.2011.43.1.001
PMID
21088470
Appears in Collections:
Journal Papers > Research Organization > Institute for Medical Sciences
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
곽, 병주이, 용범
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