19 284

Cited 59 times in

Microglial phagocytosis is enhanced by monomeric alpha-synuclein, not aggregated alpha-synuclein: implications for Parkinson's disease.

Authors
Park, JY; Paik, SR; Jou, I; Park, SM
Citation
Glia, 56(11):1215-1223, 2008
Journal Title
Glia
ISSN
0894-14911098-1136
Abstract
Gathering evidence has associated activation of microglia with the pathogenesis of numerous neurodegenerative diseases of the central nervous system (CNS) such as Alzheimer's disease and Parkinson's disease. Microglia are the resident macrophages of the CNS whose functions include chemotaxis, phagocytosis, and secretion of a variety of cytokines and proteases. In this study, we examined the possibility that alpha-synuclein (alpha-syn), which is associated with the pathogenesis of Parkinson's disease, may affect the phagocytic function of microglia. We found that extracellular monomeric alpha-syn enhanced microglial phagocytosis in both a dose- and time-dependent manner, but beta- and gamma- syn did not. We also found that the N-terminal and NAC region of alpha-syn, especially the NAC region, might be responsible for the effect of alpha-syn on microglial phagocytosis. In contrast to monomeric alpha-syn, aggregated alpha-syn actually inhibited microglial phagocytosis. The different effects of monomeric and aggregated alpha-syn on phagocytosis might be related to their localization in cells. This study indicates that alpha-syn can modulate the function of microglia and influence inflammatory changes such as those seen in neurodegenerative disorders.
MeSH terms
AnimalsCell LineCells, CulturedHumansMiceMicroglia/pathologyMicroglia/physiology*Neurodegenerative Diseases/metabolismNeurodegenerative Diseases/pathology*Parkinson Disease*/pathologyPhagocytosis/physiology*Protein Isoforms/chemistryProtein Isoforms/physiologyRatsRats, Sprague-Dawleyalpha-Synuclein/chemistry*alpha-Synuclein/physiology*
DOI
10.1002/glia.20691
PMID
18449945
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
주일로박상면
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse