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Vitamin D may not be a good marker of disease activity in Korean patients with systemic lupus erythematosus.

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dc.contributor.authorKim, HA-
dc.contributor.authorSung, JM-
dc.contributor.authorJeon, JY-
dc.contributor.authorYoon, JM-
dc.contributor.authorSuh, CH-
dc.date.accessioned2012-04-26T01:00:05Z-
dc.date.available2012-04-26T01:00:05Z-
dc.date.issued2011-
dc.identifier.issn0172-8172-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6572-
dc.description.abstractVitamin D is a pleiotrophic hormone with immunoregulatory properties. Low levels of vitamin D have been discovered in various autoimmune diseases. Here, we investigated serum vitamin D levels in Koreans with systemic lupus erythematosus (SLE) and examined whether levels correlate with disease activity of SLE. Blood samples were prospectively collected from patients with SLE (n = 104) and normal controls (NC, n = 49) during the spring from March to May 2008. The level of serum 25-hydroxyvitamin D (25(OH)D3) was measured by radioimmunoassay. The serum 25(OH)D3 levels of patients with SLE (42.49 ± 15.08 ng/ml) were significantly lower than NC (52.72 ± 15.19 ng/ml, P < 0.001). Additionally, 17 patients with SLE (16.3%) had vitamin D insufficiency, while two NC had vitamin D insufficiency (4.1%). The risk of vitamin D insufficiency was 4.6-fold increased in SLE (P = 0.032). The serum 25(OH)D3 levels, adjusted with BMI, were positively correlated only with hemoglobin (β = 0.256, P = 0.018) and serum complement 3 (β = 0.365, P = 0.002). Serum vitamin D levels were lower, and vitamin D insufficiency was more common in Korean patients with SLE, however, our study demonstrated that vitamin D levels might not be a good marker of disease activity.-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHBiological Markers-
dc.subject.MESHComplement C3-
dc.subject.MESHFemale-
dc.subject.MESHHemoglobins-
dc.subject.MESHHumans-
dc.subject.MESHLupus Erythematosus, Systemic-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHVitamin D-
dc.subject.MESHVitamin D Deficiency-
dc.titleVitamin D may not be a good marker of disease activity in Korean patients with systemic lupus erythematosus.-
dc.typeArticle-
dc.identifier.pmid20352222-
dc.contributor.affiliatedAuthor김, 현아-
dc.contributor.affiliatedAuthor서, 창희-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00296-010-1442-1-
dc.citation.titleRheumatology international-
dc.citation.volume31-
dc.citation.number9-
dc.citation.date2011-
dc.citation.startPage1189-
dc.citation.endPage1194-
dc.identifier.bibliographicCitationRheumatology international, 31(9). : 1189-1194, 2011-
dc.identifier.eissn1437-160X-
dc.relation.journalidJ001728172-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
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