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Association between variable number tandem repeats within the 3' flanking region of the interleukin-6 gene and systemic lupus erythematosus in Korean patients.

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dc.contributor.authorJeon, JY-
dc.contributor.authorKim, HA-
dc.contributor.authorKim, SH-
dc.contributor.authorSuh, CH-
dc.date.accessioned2012-04-26T01:03:29Z-
dc.date.available2012-04-26T01:03:29Z-
dc.date.issued2011-
dc.identifier.issn0961-2033-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6574-
dc.description.abstractVariable number tandem repeat (VNTR) polymorphism located in the 3' flanking region of the interleukin-6 (IL-6) gene was examined in Koreans with systemic lupus erythematosus (SLE). We identified 15 VNTR alleles (K1 to K15) in the 3' flanking region by Genescan analysis. The VNTR K8 allele, a 648-base pair (bp) allele, was most commonly found in Koreans, being present in 74.8% of the SLE patients and 70.3% of the normal controls. The VNTR K9 (642 bp) allele was associated with susceptibility to SLE. In addition, the VNTR K9 was significantly associated with leukopenia (p = 0.048), thrombocytopenia (p = 0.020), and elevated C-reactive protein (p = 0.019). These data suggest that the VNTR K9 in the 3' flanking region of the IL-6 gene may be associated with disease susceptibility and the clinical phenotypes of SLE.-
dc.language.isoen-
dc.subject.MESH3' Flanking Region-
dc.subject.MESHAdult-
dc.subject.MESHAlleles-
dc.subject.MESHAsian Continental Ancestry Group/genetics-
dc.subject.MESHBase Sequence-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDNA Primers/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Association Studies-
dc.subject.MESHHumans-
dc.subject.MESHInterleukin-6/*genetics-
dc.subject.MESHLupus Erythematosus, Systemic/*genetics/*immunology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESH*Minisatellite Repeats-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHYoung Adult-
dc.titleAssociation between variable number tandem repeats within the 3' flanking region of the interleukin-6 gene and systemic lupus erythematosus in Korean patients.-
dc.typeArticle-
dc.identifier.pmid21700657-
dc.identifier.urlhttp://lup.sagepub.com/cgi/pmidlookup?view=long&pmid=21700657-
dc.contributor.affiliatedAuthor김, 현아-
dc.contributor.affiliatedAuthor김, 승현-
dc.contributor.affiliatedAuthor서, 창희-
dc.type.localJournal Papers-
dc.identifier.doi10.1177/0961203311405704-
dc.citation.titleLupus-
dc.citation.volume20-
dc.citation.number11-
dc.citation.date2011-
dc.citation.startPage1161-
dc.citation.endPage1165-
dc.identifier.bibliographicCitationLupus, 20(11):1161-1165, 2011-
dc.identifier.eissn1477-0962-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > Research Organization > Regional Clinical Trial Center
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