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Replicated association between genetic variation in the PARK2 gene and blood pressure.

Authors
Jin, HS; Hong, KW; Kim, BY; Kim, J; Yoo, YH; Oh, B; Jeong, SY
Citation
Clinica chimica acta: international journal of clinical chemistry, 412(17-18):1673-1677, 2011
Journal Title
Clinica chimica acta: international journal of clinical chemistry
ISSN
0009-89811873-3492
Abstract
BACKGROUND: The PARK2 gene encodes Parkin which is linked to the mitochondrial fusion, fission and mitophagy. In the previous study, single nucleotide polymorphisms (SNPs) in the PARK2 gene have been reported to be associated with blood pressure (BP) in Nigerian families. We aimed to confirm whether the genetic variation of the PARK2 gene influenced the susceptibility to BP and hypertension in Korean population.



METHODS: We performed the quantitative BP trait analysis and hypertension case-control analysis for the 227 SNPs in the PARK2 gene in the Korean Association Resource (KARE) cohort (8512 subjects) and the Korean Urban Epidemiology (KUE) cohort (3703 subjects) by the independent association analysis and meta-analysis.



RESULTS: Two SNPs, rs9456721 and rs6902041, were significantly associated with systolic BP (SBP) and diastolic BP (DBP), respectively, in the KARE subjects, and their association p-values were below the Bonferroni-corrected significance level. The replication analysis in the KUE subjects revealed a significant association between the SNP, rs6902041 and BP.



CONCLUSIONS: These results indicate that genetic variation in the PARK2 gene is significantly associated with BP not only in the Nigerian population but also in the Korean population. This study may provide insight into the genetic basis of hypertension related to the mitochondrial quality control.
MeSH terms
AdultBlood Pressure/*geneticsCase-Control StudiesCohort StudiesFemale*Genetic VariationHumansMaleMiddle AgedNigeriaPolymorphism, Single NucleotideRepublic of KoreaUbiquitin-Protein Ligases/*genetics
DOI
10.1016/j.cca.2011.05.026
PMID
21635879
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
AJOU Authors
진, 현석정, 선용
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