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Monitoring of altered free fatty acid metabolic patterns in rat plasma following hemorrhagic stroke.

Authors
Paik, MJ; Shin, JY; Lee, G; Ahn, YH
Citation
Analytical letters, 44(7):1323-1332, 2011
Journal Title
Analytical letters
ISSN
0003-27191532-236X
Abstract
To uncover the physiological changes occurring after hemorrhagic stroke, we analyzed 24 free fatty acids in plasma as tert-butyldimethylsilyl derivatives by gas chromatography-mass spectrometry from control and intracerebral hemorrhage rats. Hematoma volume decreased, and hemorrhage-induced behavioral abnormalities recovered overtime. Altered fatty acid metabolism at 7 days after hemorrhagic stroke spontaneously recovered to normal control levels at 14 days. The deformed star patterns of hemorrhagic stroke group were readily distinguished from the tetracosagonal shape of the control mean. Thus, the present method may be used for monitoring of biochemical and physiological events in hemorrhagic stroke.
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
AJOU Authors
이, 광안, 영환
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