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Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

Authors
Kang, ES; Kim, MS; Kim, CH; Nam, CM; Han, SJ; Hur, KY; Ahn, CW; Cha, BS; Kim, SI; Lee, HC; Kim, YS
Citation
Transplantation, 88(5):693-698, 2009
Journal Title
Transplantation
ISSN
0041-13371534-6080
Abstract
BACKGROUND: Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea.



MATERIALS AND METHODS: A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rs13266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892.



RESULTS: Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P =0.016), SLC30A8 rs13266634 (OR=1.52, P =0.003), HHEX rs1111875 (OR=1.47, P =0.007), HHEX rs7923837 (OR=2.32, P =0.014), HHEX rs5015480 (OR=1.59, P =0.003), CDKAL1 rs10946398 (OR=1.43, P =0.008), CDKN2A/B rs10811661 (OR=1.33, P =0.039), and KCNQ1 rs2237892 (OR=1.46, P =0.009).



CONCLUSIONS: These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.
MeSH terms
AdultCohort StudiesDiabetes Complications/genetics*Diabetes Mellitus, Type 2/etiologyDiabetes Mellitus, Type 2/genetics*FemaleGenetic Predisposition to Disease*GenotypeGlucose/metabolismHumansKidney Transplantation/methods*KoreaMaleMiddle AgedPolymorphism, Single NucleotideRenal Insufficiency/complications*Renal Insufficiency/therapy
DOI
10.1097/TP.0b013e3181b29c41
PMID
19741467
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
한, 승진
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