65 401

Cited 0 times in

Selective 3,4-Dihydroxyphenylalanine Analysis in Human Urine as Ethoxycarbonyl-tert-butyldimethylsilyl Derivatives by Gas Chromatography-Mass Spectrometry.

DC Field Value Language
dc.contributor.authorPaik, MJ-
dc.contributor.authorNguyen, DT-
dc.contributor.authorYoon, J-
dc.contributor.authorCho, IS-
dc.contributor.authorShim, W-
dc.contributor.authorKim, KR-
dc.contributor.authorCho, KH-
dc.contributor.authorChoi, S-
dc.contributor.authorLee, G-
dc.date.accessioned2012-04-26T02:17:19Z-
dc.date.available2012-04-26T02:17:19Z-
dc.date.issued2011-
dc.identifier.issn0253-2964-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6590-
dc.description.abstractA new analytical method for measurement of 3,4-dihydroxyphenylalanine (DOPA) in human urine was developed. DOPA from an aqueous solution was converted into an ethoxycarbonyl (EOC) derivative. A tert-butyldimethylsilyl (TBDMS) reaction under anhydrous conditions was then attempted for analysis by gas chromatography-mass spectrometry in selected ion monitoring mode. A new mass spectral data on DOPA as a tri-EOC/mono-TBDMS derivative was built. This method showed good linearity (r ≥ 0.999), precision (% relative standard deviation = 3.1-9.2), and accuracy (% relative error = −7.2-8.8), with a detection limit of 0.05ng/mL. This selective and accurate method of DOPA analysis will be useful for biochemical monitoring of various neurological disorders including Parkinson’s disease in biological fluids.-
dc.language.isoen-
dc.titleSelective 3,4-Dihydroxyphenylalanine Analysis in Human Urine as Ethoxycarbonyl-tert-butyldimethylsilyl Derivatives by Gas Chromatography-Mass Spectrometry.-
dc.typeArticle-
dc.identifier.urlhttp://journal.kcsnet.or.kr/main/j_search/j_archives.htm?qpage=j_search&spage=b_bkcs&dpage=ar-
dc.contributor.affiliatedAuthor조, 기홍-
dc.contributor.affiliatedAuthor이, 광-
dc.type.localJournal Papers-
dc.citation.titleBulletin of the Korean Chemical Society-
dc.citation.volume32-
dc.citation.number3-
dc.citation.date2011-
dc.citation.startPage977-
dc.citation.endPage980-
dc.identifier.bibliographicCitationBulletin of the Korean Chemical Society, 32(3):977-980, 2011-
dc.identifier.eissn1229-5949-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Neurosurgery
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Files in This Item:
Bulletin of the Korean Chemical Society_32(3)_977-980.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse