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First three reported cases of nosocomial fungemia caused by Candida auris.

Authors
Lee, WG; Shin, JH; Uh, Y; Kang, MG; Kim, SH; Park, KH; Jang, HC
Citation
Journal of clinical microbiology, 49(9):3139-3142, 2011
Journal Title
Journal of clinical microbiology
ISSN
0095-11371098-660X
Abstract
Candida auris is a newly described species whose clinical significance is not clear. Here, we describe the first three cases of nosocomial fungemia caused by C. auris, which confirms that it is a causative agent of bloodstream infections. All three patients presented persistent fungemia for 10 to 31 days. The isolates obtained from the three patients were misidentified as Candida haemulonii and Rhodotorula glutinis by the Vitek 2 and the API 20C systems, respectively. C. auris was confirmed by sequence analysis of the internal transcribed spacer region and D1/D2 regions of the 26S ribosomal DNA of the rRNA gene. The MIC ranges of amphotericin B (AMB), fluconazole (FLU), itraconazole, and voriconazole were 0.5 to 1, 2 to 128, 0.125 to 2, and 0.06 to 1 μg/ml, respectively. All isolates were susceptible to caspofungin (MIC = 0.06 μg/ml) and micafungin (MIC = 0.03 μg/ml). One patient developed breakthrough fungemia while receiving FLU therapy, and two patients who received FLU therapy followed by AMB showed therapeutic failure and fatal outcomes. Our cases show that C. auris fungemia can be persistent, despite FLU or AMB therapy, which emphasizes the importance of accurately identifying this species.
MeSH terms
AgedAntifungal Agents/pharmacologyCandida/*classification/*isolation & purificationCandidemia/*diagnosis/*microbiology/pathologyCross Infection/*diagnosis/*microbiology/pathologyDNA, Fungal/chemistry/geneticsDNA, Ribosomal Spacer/chemistry/geneticsDiagnostic ErrorsFemaleHumansInfantMaleMicrobial Sensitivity TestsMycological Typing Techniques/methodsSequence Analysis, DNA
DOI
10.1128/JCM.00319-11
PMID
21715586
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Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
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