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The usefulness of albumin-adjusted ischemia-modified albumin index as early detecting marker for ischemic stroke.

Authors
Ahn, JH; Choi, SC; Lee, WG; Jung, YS
Citation
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 32(1):133-138, 2011
Journal Title
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN
1590-18741590-3478
Abstract
This study was conducted to investigate whether albumin-adjusted ischemia-modified albumin index (IMA index) is more sensitive and accurate than ischemia-modified albumin (IMA) as early detection marker of ischemic stroke, and to compare IMA and IMA index in progression and non-progression of ischemic stroke. This case-control study was done at an emergency medical center of a university hospital. 52 patients with neurological symptoms were enrolled (28 Ischemic Stroke Group and 24 Non-Stroke Group). In the ROC analysis of IMA index to diagnose stroke, area under the curve (AUC) was 0.990 (cutoff value 91.4; 95% CI: 0.970-1.000; sensitivity: 96.4%; specificity 95.8%). The AUC for IMA value was 0.928 (cutoff value 98 U/ml; 95% CI 0.857-0.999; sensitivity 89.3%; specificity 88.5%). [corrected] The difference between progression (n = 12) and non-progression group (n = 16) in IMA and IMA index were statistically insignificant (p > 0.01). IMA index was more sensitive than conventional IMA value as diagnostic biomarker of stroke, however, arguable as a predictive biomarker for progression of ischemic stroke.
MeSH terms
AdultAgedBiological Markers/analysisBrain/pathologyEarly DiagnosisFemaleHumansIschemia/complicationsMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesROC CurveSerum Albumin/*analysisStatistics, NonparametricStroke/*diagnosis/etiology
DOI
10.1007/s10072-010-0457-4
PMID
21153598
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Emergency Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
AJOU Authors
안, 정환최, 상천이, 위교정, 윤석
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