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Changes of body weight and inflammatory markers after 12-week intervention trial: results of a double-blind, placebo-control pilot study.

Authors
Joo, NS; Kim, SM; Kim, KM; Kim, CW; Kim, B; Lee, DJ
Citation
Yonsei medical journal, 52(2):242-248, 2011
Journal Title
Yonsei medical journal
ISSN
0513-57961976-2437
Abstract
PURPOSE: Low grade inflammation is a well-known characteristic in obese subjects. We investigated body weight changes and inflammatory markers after 12-week intervention trial.



MATERIALS AND METHODS: Twenty-six obese subjects were enrolled and 19 (13 men and 6 women) completed the study. Sibutramine is an FDA-approved drug for body weight control; therefore, we chose this drug as the standard treatment medication in this study. Patients were randomly allocated to receive an anti-inflammatory agent (Diacerein treatment group; n = 12) or placebo (n = 7) for 12 weeks. Anthropometry, body proportion by dual-energy X-ray absorptiometry, and metabolic parameters at the beginning and end of study were measured and compared.



RESULTS: The treatment group had a tendency towards more reduction in anthropometry as compared to the placebo group, in body weight reduction (-7.0 kg vs. -4.6 kg), body mass index (-2.51 kg/m² vs. -1.59 kg/m²), and waist circumference (-7.3 cm vs. -4.4 cm). These reductions were not statistically significant. Changes in levels of high-sensitivity C-reactive protein and adiponectin in the treatment group were more favorable than in the placebo group.



CONCLUSION: This small pilot study showed no statistical difference for changes in anthropometry, and inflammatory markers between the two groups. Therefore, we could not find any additional effects of Diacerein on weight loss and inflammatory variables in this study.
MeSH terms
Absorptiometry, PhotonAdiponectin/bloodAdultAnthraquinones/*therapeutic useAnti-Inflammatory Agents/*therapeutic useAppetite Depressants/therapeutic useC-Reactive Protein/analysisCyclobutanes/*therapeutic useDouble-Blind MethodFemaleHumansInflammationLipoproteins, LDL/bloodMaleObesity/*drug therapy/immunologyPilot ProjectsTumor Necrosis Factor-alpha/bloodWaist Circumference/drug effects/immunologyWeight Loss/drug effects/*immunology
DOI
10.3349/ymj.2011.52.2.242
PMID
21319341
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
AJOU Authors
주, 남석김, 광민김, 범택이, 득주
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