226 253

Cited 16 times in

Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old.

Authors
Je, SH; Joo, NS; Choi, BH; Kim, KM; Kim, BT; Park, SB; Cho, DY; Kim, KN; Lee, DJ
Citation
Journal of Korean medical science, 26(8):1093-1098, 2011
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
There are inconsistent findings on the effects of vitamin K on bone mineral density (BMD) and undercarboxylated osteocalcin (UcOC). The present intervention study evaluated the effect in subjects over 60-yr-old. The vitamin K group (vitamin K + vitamin D + calcium supplement; 15 mg of vitamin K2 [menatetrenone] three times daily, 400 IU of vitamin D once a day, and 315 mg of calcium twice daily) and the control group (vitamin D + calcium supplement) were randomly assigned. During the six months of treatment, seventy eight women participated (38 in the vitamin K group and 40 in the control group) and 45 women completed the study. The baseline characteristics of study participants did not differ between the vitamin K and the control groups. In a per protocol analysis after 6 months, L3 bone mineral density has increased statistically significantly in the vitamin K group compared to the control group (0.01 ± 0.03 g/cm(2) vs -0.008 ± 0.04 g/cm(2), P = 0.049). UcOC concentration was also significantly decreased in the vitamin K group (-1.6 ± 1.6 ng/dL vs -0.4 ± 1.1 ng/dL, P = 0.008). In conclusion, addition of vitamin K to vitamin D and calcium supplements in the postmenopausal Korean women increase the L3 BMD and reduce the UcOC concentration.
MeSH terms
AgedBone Density/*drug effectsCalcium/*administration & dosageDietary SupplementsFemaleHumansMiddle AgedOsteocalcin/*bloodPostmenopauseRepublic of KoreaVitamin D/*administration & dosageVitamin K/*administration & dosage
DOI
10.3346/jkms.2011.26.8.1093
PMID
21860562
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
AJOU Authors
제, 상현주, 남석김, 광민김, 범택박, 샛별조, 두연김, 규남이, 득주
Full Text Link
Files in This Item:
1093-1098.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse