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Serum gamma-glutamyltransferase concentration correlates with Framingham risk score in Koreans.

Authors
Kim, KN; Kim, KM; Lee, DJ; Joo, NS
Citation
Journal of Korean medical science, 26(10):1305-1309, 2011
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Gamma-glutamyltransferase (GGT) is a novel coronary artery disease (CAD) risk factor, but its use as an independent factor for CAD risk prediction remains unclear in Asian population. This study examined the association between serum GGT concentration and Framingham risk score (FRS) in the Korean population. This cross-sectional study was performed on 30,710 Koreans. Besides FRS, body mass index, fasting blood glucose, liver enzymes, lipid profile, uric acid and high sensitive C-reactive protein data were used. The study subjects were grouped into quartiles according to the levels of GGT. Analyses relating GGT to FRS ≥ 20% utilized multiple confounders adjusted logistic regression. Positive correlations were established between log-transformed GGT concentration and FRS (r = 0.38; P < 0.001). Increasing the quartile of serum GGT concentration was significantly associated with linear increasing trends in FRS (P-trend < 0.001). Compared to the lowest baseline GGT category, age-gender adjusted odd ratios for FRS ≥ 20% were significantly increased from the lowest to highest GGT quartiles; these results remained significantly after adjustments for multiple confounders. Increased GGT concentration is associated with the increase in FRS. Serum GGT may be helpful to predict the future risk of CAD.
MeSH terms
AdultAgedAged, 80 and overBlood Glucose/analysisBody Mass IndexC-Reactive Protein/analysisCoronary Artery Disease/enzymology/*epidemiologyCross-Sectional StudiesFemaleHumansLipids/bloodLiver/enzymologyMaleMiddle AgedRepublic of Korea/epidemiologyRisk FactorsUric Acid/bloodgamma-Glutamyltransferase/*blood
DOI
10.3346/jkms.2011.26.10.1305
PMID
22022182
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Family Practice & Community Health
AJOU Authors
김, 규남김, 광민이, 득주주, 남석
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