80 504

Cited 28 times in

Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria.

DC Field Value Language
dc.contributor.authorPark, JM-
dc.contributor.authorWon, SC-
dc.contributor.authorShin, JI-
dc.contributor.authorYim, H-
dc.contributor.authorPai, KS-
dc.date.accessioned2012-04-30T01:35:01Z-
dc.date.available2012-04-30T01:35:01Z-
dc.date.issued2011-
dc.identifier.issn0931-041X-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6634-
dc.description.abstractTo evaluate the therapeutic role of cyclosporin A (CyA) for the treatment of Henoch-Schönlein nephritis (HSN), 29 patients (18 boys, 11 girls) with nephrotic-range proteinuria were analyzed retrospectively. Mean age was 8.6 years (range 2.0-15.5 years) at diagnosis of Henoch-Schönlein purpura (HSP). All patients had developed the nephrotic-range proteinuria at a mean interval of 4.4 months (range 0-50.7 months) after the diagnosis of HSP. Mean duration of CyA treatment was 12.3 months (range 2.6-55.0 months). Mean follow-up times were 3.7 years (range 1.2-12.9 years) from the beginning of the CyA treatment. Steroids were tapered off and stopped gradually after initiation of CyA. All patients responded to the CyA treatment within a mean of 1.8 months (range 1 week to 3.5 months). Twenty-three patients achieved stable remission with mean follow-up duration of 3.2 years and 6 patients seemed to become CyA-dependent, since they developed proteinuria when the treatment was stopped. Renal function was preserved in all patients but one who developed end-stage renal disease after poor compliance with CyA. We concluded that CyA treatment for HSN showing nephrotic-range proteinuria is very effective and a safe method, although some patients become CyA-dependent.-
dc.language.isoen-
dc.subject.MESHAdolescent-
dc.subject.MESHBiopsy-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCyclosporine/adverse effects/*therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/adverse effects/*therapeutic use-
dc.subject.MESHMale-
dc.subject.MESHNephritis/diagnosis/*drug therapy/etiology-
dc.subject.MESHNephrotic Syndrome/diagnosis/*drug therapy/etiology-
dc.subject.MESHProteinuria/diagnosis/*drug therapy/etiology-
dc.subject.MESHPurpura, Schoenlein-Henoch/complications/diagnosis/*drug therapy-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.titleCyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria.-
dc.typeArticle-
dc.identifier.pmid21184240-
dc.contributor.affiliatedAuthor임, 현이-
dc.contributor.affiliatedAuthor배, 기수-
dc.type.localJournal Papers-
dc.identifier.doi10.1007/s00467-010-1723-7-
dc.citation.titlePediatric nephrology (Berlin, Germany)-
dc.citation.volume26-
dc.citation.number3-
dc.citation.date2011-
dc.citation.startPage411-
dc.citation.endPage417-
dc.identifier.bibliographicCitationPediatric nephrology (Berlin, Germany), 26(3):411-417, 2011-
dc.identifier.eissn1432-198X-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Files in This Item:
21184240.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse