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Non-catch-up growth in intrauterine growth-retarded rats showed glucose intolerance and increased expression of PDX-1 mRNA.

DC Field Value Language
dc.contributor.authorLim, JS-
dc.contributor.authorLee, JA-
dc.contributor.authorHwang, JS-
dc.contributor.authorShin, CH-
dc.contributor.authorYang, SW-
dc.date.accessioned2012-04-30T02:24:16Z-
dc.date.available2012-04-30T02:24:16Z-
dc.date.issued2011-
dc.identifier.issn1328-8067-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6642-
dc.description.abstractBACKGROUND:   Children born with intrauterine growth retardation (IUGR) show long-term complications like non-catch-up growth and type 2 diabetes. We hypothesize that the duration of malnutrition influences the growth and pancreatic development in IUGR. The pancreatic duodenal homeobox-1 (PDX-1) expression might also be different because it links glucose metabolism to the regulation of insulin gene transcription in the pancreas.



METHODS:   We made an IUGR rat model with a low-protein diet (8% casein) during gestational periods. Catch-up rats (CU) were given normal lab chow immediately after birth. Non-catch-up rats (NCU) were given normal lab chow after lactation periods. PDX-1 mRNA level, islet areas and intravenous glucose tolerance test (IVGTT) were assessed in each group and compared with control rats (C) at the 16th week.



RESULTS:   The weight and length of CU and C rats were not different after 3 weeks, while NCU rats were smaller than C and CU rats (P < 0.05). In IVGTT, the 20-min and 50-min glucose level and area under the curve for glucose were increased in NCU rats compared with those values in C and CU rats (P < 0.05). The islet area of NCU rats was smaller than that of C and CU rats (P < 0.05). In contrast, PDX-1 mRNA levels of NCU rats were higher than those of C rats (P < 0.05). CU rats showed normal glucose response in IVGTT with increased islet number and size.



CONCLUSIONS:   IUGR rats that failed to undergo catch-up growth might be prone to abnormal glucose tolerance, decreased islet size, and increased PDX-1 mRNA levels in early adult life.
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dc.language.isoen-
dc.subject.MESHAnimals-
dc.subject.MESHBody Weight-
dc.subject.MESHDiabetes Mellitus, Type 2-
dc.subject.MESHDiet, Protein-Restricted-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHFetal Growth Retardation-
dc.subject.MESHGlucose Intolerance-
dc.subject.MESHGlucose Tolerance Test-
dc.subject.MESHGrowth-
dc.subject.MESHHomeodomain Proteins-
dc.subject.MESHInsulin Resistance-
dc.subject.MESHIslets of Langerhans Transplantation-
dc.subject.MESHLactation-
dc.subject.MESHMale-
dc.subject.MESHMalnutrition-
dc.subject.MESHRNA, Messenger-
dc.subject.MESHRats-
dc.subject.MESHRats, Wistar-
dc.subject.MESHTrans-Activators-
dc.titleNon-catch-up growth in intrauterine growth-retarded rats showed glucose intolerance and increased expression of PDX-1 mRNA.-
dc.typeArticle-
dc.identifier.pmid20626638-
dc.identifier.urlhttp://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1328-8067&date=2011&volume=53&issue=2&spage=181-
dc.contributor.affiliatedAuthor황, 진순-
dc.type.localJournal Papers-
dc.identifier.doi10.1111/j.1442-200X.2010.03204.x-
dc.citation.titlePediatrics international-
dc.citation.volume53-
dc.citation.number2-
dc.citation.date2011-
dc.citation.startPage181-
dc.citation.endPage186-
dc.identifier.bibliographicCitationPediatrics international, 53(2). : 181-186, 2011-
dc.identifier.eissn1442-200X-
dc.relation.journalidJ013288067-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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