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Stem-like tumor cells confer drug resistant properties to mantle cell lymphoma.

Authors
Jung, HJ; Chen, Z; McCarty, N
Citation
Leukemia & lymphoma, 52(6):1066-1079, 2011
Journal Title
Leukemia & lymphoma
ISSN
1042-81941029-2403
Abstract
We recently identified clonogenic malignant stem cell populations in human mantle cell lymphoma (MCL), a particularly deadly subtype of non-Hodgkin lymphoma (NHL). We discovered that CD45+CD19- MCL cells, which we termed MCL-initiating cells (MCL-ICs), are highly tumorigenic and display self-renewal capacity in vivo; in contrast, CD45+CD19+ MCL cells, which constitute the vast majority of cells within the tumors, show no self-renewal capacity and greatly reduced tumorigenicity. Given the newly appreciated role of cancer-initiating cells in the drug resistance of cancers, it is critical to investigate whether CD45+CD19- MCL-ICs play a role in the drug resistance of human MCL. We discovered that MCL-ICs were more resistant to clinically relevant chemotherapeutic agents, in combination or in a single regimen, compared to CD45+CD19+ cells, and that this drug resistance was largely due to quiescent properties with enriched ABC transporters. In conclusion, designing novel therapies to kill CD45+CD19- MCL-ICs may prevent relapse and increase patient survival.
MeSH terms
Antigens, CD19/metabolismAntigens, CD45/metabolismAntineoplastic Combined Chemotherapy Protocols/pharmacologyCell Survival/drug effectsCells, CulturedDose-Response Relationship, Drug*Drug Resistance, NeoplasmFlow Cytometry*Gene Expression Regulation, NeoplasticHumansInhibitory Concentration 50Lymphoma, Mantle-Cell/genetics/metabolism/pathologyNeoplastic Stem Cells/drug effects/*metabolism/pathologyP-Glycoprotein/*geneticsReverse Transcriptase Polymerase Chain Reaction
DOI
10.3109/10428194.2011.562570
PMID
21599592
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
정, 현주
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