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Topiramate on the quality of life in childhood epilepsy.

Authors
Jung, DE; Kim, HD; Hur, YJ; Eom, SY; Korean Pediatric Topiramate Study Group
Citation
Brain & development, 33(9):707-712, 2011
Journal Title
Brain & development
ISSN
0387-76041872-7131
Abstract
This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664 children with epilepsy from 41 centers was conducted. The parents completed the K-QOLCE at the baseline visit and again 6months after starting TPM treatment. The parents reported the seizure frequency at both assessment dates. Statistically significant improvements in all K-QOLCE domains except social functioning were found at 6months after starting TPM treatment from the baseline-scores (P<0.05). However, improved QOL scores were not dependent on the reduction in seizure frequency. TPM significantly improved QOL in children with epilepsy, suggesting its potential clinical benefits.
MeSH terms
AdolescentAnticonvulsants/*therapeutic useChildChild, PreschoolEpilepsy/*drug therapy/*psychologyFemaleFructose/*analogs & derivatives/therapeutic useHumansMaleProspective Studies*Quality of LifeQuestionnairesTreatment Outcome
DOI
10.1016/j.braindev.2010.11.011
PMID
21194859
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
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