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Acute promyelocytic leukemia with complex translocation t(5

Authors
Cho, SR; Park, SJ; Kim, HJ; Park, IJ; Choi, JR; Jung, HJ; Park, JE
Citation
Journal of pediatric hematology/oncology, 33(7):e326-e329, 2011
Journal Title
Journal of pediatric hematology/oncology
ISSN
1077-41141536-3678
Abstract
The t(15;17)(q22;q21), resulting in PML-RARA fusion gene, is a characteristic chromosomal translocation in acute promyelocytic leukemia (APL). We report a pediatric APL case with a 3-way translocation: t(5;17;15)(q35;q21;q22). Complete blood cell counts of a 12-year-old girl, of pale appearance, showed pancytopenia with increased blasts. Morphology and immunophenotype of the leukemic cells were compatible with APL. Karyotype analysis showed t(5;17;15)(q35;q21;q22) and add(7)(q32). We detected the PML-RARA fusion gene by both reverse transcriptase-polymerase chain reaction and fluorescent in situ hybridization analysis. The patient underwent successful treatment with cytarabine with all-trans retinoic acid and anthracycline-based therapy.
MeSH terms
Antineoplastic Combined Chemotherapy Protocols/therapeutic useChildChromosomes, Human, Pair 15/*geneticsChromosomes, Human, Pair 17/*geneticsChromosomes, Human, Pair 5/*geneticsFemaleHumansIn Situ Hybridization, FluorescenceLeukemia, Promyelocytic, Acute/diagnosis/drug therapy/*geneticsReverse Transcriptase Polymerase Chain Reaction
DOI
10.1097/MPH.0b013e31820998de
PMID
21617563
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Laboratory Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Genetics
AJOU Authors
조, 성란김, 현주박, 일중정, 현주박, 준은
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